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- W2079867580 abstract "Rat granulosa cells were incubated with isoquinolinesulfonamide inhibitors of protein kinases A and C and/or LH, dibutyryl cAMP (dbcAMP), tetradecan-oylphorbol acetate (TPA), cholera toxin, or forskolin for 5 h. H7 (25 μM) was observed to inhibit LH, cholera toxin or dbcAMP stimulation of prostaglandin (PGE), and progesterone accumulation. H7 produced inhibition when added as little as 2 min before and as long as 1 h after LH. HA1004 was ineffective against LH or cholera toxin stimulation of PGE or progesterone at up to 100 μM. H9 blocked some LH and forskolin responses at 25 μM, but required a 50 μM concentration to minimally affect TPA stimulation. Cytotoxicity was not observed at the concentrations and times of isoquinolinesulfonamides tested. H7 and H9, therefore, suppress LH stimulation of granulosa cell functions in a dose- and time-dependent manner consistent with inhibition of protein kinases A and/or C, and consonant with a requirement for such kinases in LH action." @default.
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- W2079867580 date "1989-11-01" @default.
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- W2079867580 title "Suppression of LH-stimulated prostaglandin and progesterone accumulation in rat granulosa cells by isoquinolinesulfonamide protein kinase inhibitors" @default.
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- W2079867580 doi "https://doi.org/10.1016/0039-128x(89)90048-2" @default.
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