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• W2079871766 startingPage "464" @default.
• W2079871766 abstract "We report a novel mutation, C1066U in 16S rRNA which was selected for resistance to spectinomycin, an antibiotic which inhibits ribosomal translocation. The minimal inhibitory concentration (MIC) of spectinomycin determined for this mutant (15 μg/ml) is greater than with the wild-type plasmid (5 μg/ml) but lower than with the well known C1192U mutation (>80 μg/ml). The C1066U mutation also increases the cells sensitivity to fusidic acid, another antibiotic which Inhibits translation at the translocation stage, whereas C1192U is unchanged relative to the wild type. We discuss why the acquisition of resistance to one of these drugs Is often associated with hypersensitivity to the other." @default.
• W2079871766 created "2016-06-24" @default.
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• W2079871766 date "1995-01-01" @default.
• W2079871766 modified "2023-09-24" @default.
• W2079871766 title "A new mutation in 16S rRNA of<i>Escherichia coli</i>conferring spectinomycin resistance" @default.
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• W2079871766 doi "https://doi.org/10.1093/nar/23.3.464" @default.
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