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- W2079871857 abstract "In contrast to astrocytic tumors, approximately two thirds of anaplastic oligodendrogliomas are reported to be chemosensitive. Relatively little is known about the genetic aberrations in oligodendroglial tumors (OTs). In order to elucidate oligodendroglial oncogenesis and to And specific genetic aberrations that may have prognostic and therapeutic implications, we performed comparative genomic hybridization (CGH) to detect chromosomal copy number changes in 17 low-grade OTs (LG-OTs) and 12 high-grade OTs (HG-OTs) lacking a prominent astrocytic component. Loss of chromosome lp (79%) and 19q (76%) were most frequently detected by CGH, all LG-OTs and 50% of the HG-OTs contained −lp (including lp36–32), −19q (including 19ql3.3), or both, and the rest of the HG-OTs showed +7, −10, or both. Since losses of lp36-32 and 19ql3.3 were mutually exclusive with +7 or −10, the HG-OTs could be divided in −lp/−19q and +7/−10 tumors. While the −1 p/− 19q tumors can be considered as pure anaplastic oligodendrogliomas, the +7/−10 tumors may rather be glioblastomas with prominent oligodendroglial differentiation. We conclude that CGH is a powerful tool to assist in the identification of 2 major subgroups of HG-OTs with prognostic and possibly therapeutic relevance." @default.
- W2079871857 created "2016-06-24" @default.
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- W2079871857 date "1999-06-01" @default.
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- W2079871857 title "Identification of Subgroups of High-grade Oligodendroglial Tumors by Comparative Genomic Hybridization" @default.
- W2079871857 doi "https://doi.org/10.1097/00005072-199906000-00005" @default.
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