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- W2079872904 abstract "The purpose of this study is to investigate the effects of normal, moderate and high doses of fluoride on rat epipyseal growth plate and surrounding bone, and to compare it with controls. In order to achieve this, 80 rats were divided into five groups (n: 16/group) and treated with 0, 1.2, 3, 50 and 100 ppm fluoridated water since birth (Groups I to V, respectively). Four rats from each group were sacrificed at 6th, 9th, 12th and 16th weeks for radiological and histopathological examinations.There was no significant variation on programmed cell death of cartilagenous components of the growth plate and chondroid matrix histopathologically between control group and fluoride-treated groups. But, minimal irregularities on the cartilage septum of primary spongiosa were detected in one rat from Group IV and one from Group V. The main histopathologic findings of the rats which were treated with high doses of fluoride were irregular lamella, variation in calcium content, minimally enlarged Haversian canals, focal osteoblastic proliferation, rare zones of woven bone on the diaphyseal cortical bone and secondary spongiosa, increase in ossicle size and minimal focal osteoblastic proliferation on the secondary ossification center. The only consistent radiological finding was relative widening and late partial fusing of the epiphyseal growth plates of high-dose treated groups at 16th week.As a result, high doses of fluoride did not directly affect chondrocyte morphology of growth plate on young rats. More sophisticated techniques would be beneficial for further investigations on this subject." @default.
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- W2079872904 date "2001-06-01" @default.
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- W2079872904 title "Effects of Fluoride on Growth Plate and Bone Histopathology in Young Rats" @default.
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- W2079872904 doi "https://doi.org/10.1016/s0218-9577(01)00046-5" @default.
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