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- W2079873073 abstract "Chemically skinned muscle fibers from rat extensor digitorum longus muscle were used to study the effects of uridine triphosphate (UTP) on Ca 2+ uptake and release by the sarcoplasmic reticulum (SR) and on Ca 2+ -activated tensions. Total replacement (2.5 mM) of adenosine triphosphate (ATP) with UTP (i) increased submaximal Ca 2+ -induced tension (pCa 6.2–5.8) but diminished P o , the maximum tension elicited by pCa 4.2, by ca. 15%; (ii) markedly reduced Ca 2+ uptake by the SR (evaluated by caffeine-elicited tension); and (iii) induced tension in Ca 2+ -loaded fibers. The UTP-induced tension averaged 55% of P o and its rates of development and decay were considerably slower than those of caffeine-evoked tension. The UTP-induced tension (i) depended on the Ca 2+ -loading conditions; (ii) was reversibiy blocked by brief (15 s) exposures of Ca 2+ -loaded fibers to 5 mM EGTA or by pretreatment with caffeine; (iii) was abolished by functional disruption of the SR with the nonionic detergent Brij-58; and (iv) persisted after blockade of the SR Ca 2+ release channels with ruthenium red. Exposure of Ca 2+ -loaded fibers to UTP depressed the tension elicited subsequently by caffeine, and enhanced the rate of depletion of caffeine-sensitive Ca 2+ stores during soaking in relaxing solutions containing 5 mM EGTA. The UTP-induced tension is attributed to increased release of Ca 2+ from the SR, via a ruthenium red insensitive pathway(s), combined with reduced Ca 2+ uptake by the SR and increased Ca 2+ affinity of the contractile proteins.Key words: skinned muscle fiber, UTP-induced tension, tension–pCa relationship, sarcoplasmic reticulum, calcium transport." @default.
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- W2079873073 date "1995-10-01" @default.
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- W2079873073 title "Effects of uridine triphosphate on skinned skeletal muscle fibers of the rat" @default.
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- W2079873073 doi "https://doi.org/10.1139/y95-202" @default.
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