FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079873376> ?p ?o ?g. }

• W2079873376 endingPage "24" @default.
• W2079873376 startingPage "17" @default.
• W2079873376 abstract "Regulation of the expression of the cytochrome P-450 la2 gene (cyp1a2) occurs mainly at the transcriptional level, but the molecular events involved in the induction process are partly unknown. Some reports have proposed involvement of post-transcriptional mechanisms [Adesnik, M. & Atchison, M. (1986) Crit. Rev. Biochem. 19, 247-305; Silver, G. & Krauter, K. S. (1990) Mol. Cell. Biol. 10, 6765-6768]. Here we report the identification of two proteins in the nuclear fraction of mouse liver, with specific binding characteristics towards CYP1A2 mRNA. The proteins have apparent molecular masses of 37 kDa and 46 kDa and exhibit a high affinity for a poly(U) motif in the 3' untranslated region of CYP1A2 mRNA. This motif seems to be important for their specific and apparently competitive binding to CYP1A2 mRNA. Treatment of mice with an inducer of CYP1A2, 3-methylcholanthrene, increases the binding of the 46-kDa protein and decreases the binding of the 37-kDa protein to the mRNA, suggesting that changes in the binding of the proteins to the mRNA could play a role in the upregulation of CYP1A2 mRNA by 3-methylcholanthrene. Phosphorylation of the 46-kDa protein, or of an intermediary factor, may play a role in its binding activity. Furthermore, the 46-kDa but not the 37-kDa protein is recognized by a monoclonal antibody against the heterogeneous nuclear ribonucleoprotein C, a nuclear protein probably involved in pre-mRNA processing. While more work is needed to understand the function of the proteins that bind to the 3' untranslated region of CYP1A2, it is possible that the 37-kDa protein has a role in the maintenance of uninduced levels of CYP1A2 mRNA, while the 46-kDa protein could be important in the maturation of elevated levels of CYP1A2 pre-mRNA, during induction." @default.
• W2079873376 created "2016-06-24" @default.
• W2079873376 creator A5020512155 @default.
• W2079873376 creator A5023252853 @default.
• W2079873376 creator A5049560924 @default.
• W2079873376 date "1997-04-01" @default.
• W2079873376 modified "2023-09-24" @default.
• W2079873376 title "Characterization of Two Nuclear Proteins that Interact with Cytochrome P-450 1A2 mRNA. Regulation of RNA Binding and Possible Role in the Expression of the Cypla2 Gene" @default.
• W2079873376 cites W1491993630 @default.
• W2079873376 cites W1498282556 @default.
• W2079873376 cites W1500018003 @default.
• W2079873376 cites W1503367288 @default.
• W2079873376 cites W1535142102 @default.
• W2079873376 cites W1546766816 @default.
• W2079873376 cites W1564159653 @default.
• W2079873376 cites W1570768358 @default.
• W2079873376 cites W1597931093 @default.
• W2079873376 cites W1600605923 @default.
• W2079873376 cites W1607694174 @default.
• W2079873376 cites W1647537327 @default.
• W2079873376 cites W1650427240 @default.
• W2079873376 cites W170767906 @default.
• W2079873376 cites W1767139161 @default.
• W2079873376 cites W1775749144 @default.
• W2079873376 cites W1783695128 @default.
• W2079873376 cites W1831176116 @default.
• W2079873376 cites W1922993929 @default.
• W2079873376 cites W1965258786 @default.
• W2079873376 cites W1968463041 @default.
• W2079873376 cites W1973592220 @default.
• W2079873376 cites W1977501093 @default.
• W2079873376 cites W1981587090 @default.
• W2079873376 cites W1982265633 @default.
• W2079873376 cites W1990914046 @default.
• W2079873376 cites W1993243592 @default.
• W2079873376 cites W1997048544 @default.
• W2079873376 cites W2001471445 @default.
• W2079873376 cites W2005299689 @default.
• W2079873376 cites W2006998778 @default.
• W2079873376 cites W2008662572 @default.
• W2079873376 cites W2023236405 @default.
• W2079873376 cites W2027300279 @default.
• W2079873376 cites W2029706883 @default.
• W2079873376 cites W2039027508 @default.
• W2079873376 cites W2051550274 @default.
• W2079873376 cites W2065937788 @default.
• W2079873376 cites W2072728868 @default.
• W2079873376 cites W2081171647 @default.
• W2079873376 cites W2085866164 @default.
• W2079873376 cites W2086671600 @default.
• W2079873376 cites W2087159552 @default.
• W2079873376 cites W2101357707 @default.
• W2079873376 cites W2119682915 @default.
• W2079873376 cites W2131481178 @default.
• W2079873376 cites W2137453133 @default.
• W2079873376 cites W214734757 @default.
• W2079873376 cites W2150093511 @default.
• W2079873376 cites W4232135772 @default.
• W2079873376 cites W4243844427 @default.
• W2079873376 cites W4249603401 @default.
• W2079873376 cites W4250804705 @default.
• W2079873376 cites W4253528055 @default.
• W2079873376 cites W53296106 @default.
• W2079873376 doi "https://doi.org/10.1111/j.1432-1033.1997.00017.x" @default.
• W2079873376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9128719" @default.
• W2079873376 hasPublicationYear "1997" @default.
• W2079873376 type Work @default.
• W2079873376 sameAs 2079873376 @default.
• W2079873376 citedByCount "19" @default.
• W2079873376 countsByYear W20798733762012 @default.
• W2079873376 countsByYear W20798733762013 @default.
• W2079873376 crossrefType "journal-article" @default.
• W2079873376 hasAuthorship W2079873376A5020512155 @default.
• W2079873376 hasAuthorship W2079873376A5023252853 @default.
• W2079873376 hasAuthorship W2079873376A5049560924 @default.
• W2079873376 hasBestOaLocation W20798733761 @default.
• W2079873376 hasConcept C104317684 @default.
• W2079873376 hasConcept C105580179 @default.
• W2079873376 hasConcept C150194340 @default.
• W2079873376 hasConcept C153911025 @default.
• W2079873376 hasConcept C22667442 @default.
• W2079873376 hasConcept C2780887552 @default.
• W2079873376 hasConcept C2909472194 @default.
• W2079873376 hasConcept C29512474 @default.
• W2079873376 hasConcept C41282012 @default.
• W2079873376 hasConcept C553089730 @default.
• W2079873376 hasConcept C55493867 @default.
• W2079873376 hasConcept C67705224 @default.
• W2079873376 hasConcept C75934600 @default.
• W2079873376 hasConcept C86339819 @default.
• W2079873376 hasConcept C86803240 @default.
• W2079873376 hasConcept C89604277 @default.
• W2079873376 hasConceptScore W2079873376C104317684 @default.
• W2079873376 hasConceptScore W2079873376C105580179 @default.
• W2079873376 hasConceptScore W2079873376C150194340 @default.
• W2079873376 hasConceptScore W2079873376C153911025 @default.
• W2079873376 hasConceptScore W2079873376C22667442 @default.
• W2079873376 hasConceptScore W2079873376C2780887552 @default.

• next