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• W2079874597 abstract "New palladium(II) complexes have been synthesized by the reaction of Pd(II) with 2-formylpyridine-4-Nethyl-thiosemicarbazone, HFo4NEt, 1. The complexes [Pd(Fo4NEt)Cl], 2, [Pd(H2Fo4NEt)(Fo4NEt)Cl2], 3 and [Pd(Fo4NEt)2], 4 have been characterised by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pd(H2Fo4NEt)(Fo4NEt)Cl2], 3 and the protonated ligand [(H2Fo4NEt)Cl], 5 have been solved by single-crystal X-ray diffraction. The cytotoxic activities of 1–4 have been evaluated for antiproliferative activity in vitro against the cells of three human cancer cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A-549 (non-small cell lung carcinoma) and a mouse L-929 (a fibroblast-like cell line cloned from strain L). The compound 3 display IC50 values in a μM range better than that of the antitumor drug cis-platin against MCF-7 and T-24 cell lines and is considered as agent with potential antitumor activity candidates for further stages of screening in vitro and/or in vivo." @default.
• W2079874597 created "2016-06-24" @default.
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• W2079874597 date "2013-03-01" @default.
• W2079874597 modified "2023-09-24" @default.
• W2079874597 title "Synthesis, structure, spectroscopic studies and cytotoxic effect of novel palladium(II) complexes with 2-formylpyridine-4-Nethyl-thiosemicarbazone: Potential antitumour agents" @default.
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• W2079874597 doi "https://doi.org/10.1016/j.poly.2012.06.068" @default.
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