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- W2079875281 abstract "The discussion covered several topics related to the formal presentations: (1) the identification of amino acid sequence ‘motifs and their possible involvement in Id expression, the origin of such motifs, and practical aspects of raising antibody probes to synthetic peptide analogues of the motifs. (2) consideration of the relatedness between the various Ids found in lupus, how closely they identify with anti-DNA specificity, and whether temporal changes in expressed Ids occur during disease progression. (3) the concept of ‘internal image as an explanation for anti-DNA Id sharing within and between species. (4) consideration of whether conserved Ids serve any evolutionary purpose. (5) consideration of whether autoantigens switch on or drive autoantibody responses. (6) consideration of whether antigenic cross-reaction between DNA and microbial structures or polyclonal B-cell activation provide explanations for the appearance of anti-DNA antibodies." @default.
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- W2079875281 date "1990-08-01" @default.
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- W2079875281 title "The characterization of DNA antibody idiotypes—A discussion" @default.
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