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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079875971> ?p ?o ?g. }

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• W2079875971 startingPage "1111" @default.
• W2079875971 abstract "‘Fragments’ refer to particularly small molecular starting points in medicinal chemistry. The small size of fragments requires adapted techniques for their screening and subsequent elaboration. The detection of the weak binding affinity of fragments for their target, and associated screening issues, have been debated at length. Since it is now clear that fragments can be developed into clinical candidates, the discussion is shifting to the design of good-quality lead compounds from fragment hits. The increasing ability to control and tailor this construction process highlights the potential benefits of fragment-based drug discovery." @default.
• W2079875971 created "2016-06-24" @default.
• W2079875971 creator A5086200893 @default.
• W2079875971 date "2011-07-01" @default.
• W2079875971 modified "2023-09-23" @default.
• W2079875971 title "The benefits of constructing leads from fragment hits" @default.
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• W2079875971 doi "https://doi.org/10.4155/fmc.11.46" @default.
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