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• W2079876772 abstract "CD8+ T cells play a crucial role in controlling intracellular pathogens. The level of memory CD8+ T cells developing after vaccination or infection influences the degree of T cell-mediated protection after secondary infection. We used defined animal models and infections/immunizations by replicating or non-replicating antigens to define on a molecular and cellular level in vivo the parameters that identify and shape long-lived CD8+ T cell memory. We show that the timing of antigen exposure during vaccination is key for the induction of long-lived T cell memory. Brief antigen exposure induced high numbers of effector cells but limited development of long-lived CD8+ memory T cells. In contrast, prolonged antigen exposure for up to 9 days induced similar numbers of effector T cells but additionally resulted in high levels of memory CD8+ T cells. Unexpectedly CD127 (IL-7Ralpha) expression on CD8+ T cells during the acute priming phase was a necessary but not sufficient requirement for entering the pool of long-lived antigen-independent memory CD8+ T cells. However, we provide strong evidence for the interpretation that programming of long-lived memory T cells was driven by low levels of transcription factor eomesodermin and protease inhibitor Spi2A as well as reduced phosphorylation of c-JUN." @default.
• W2079876772 created "2016-06-24" @default.
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• W2079876772 date "2006-03-29" @default.
• W2079876772 modified "2023-10-14" @default.
• W2079876772 title "Long-lived memory CD8+ T cells are programmed by prolonged antigen exposure and low levels of cellular activation" @default.
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• W2079876772 doi "https://doi.org/10.1002/eji.200535730" @default.
• W2079876772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16552716" @default.
• W2079876772 hasPublicationYear "2006" @default.
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