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- W2079882259 abstract "A protein precipitation, liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed and validated for the determination of eprosartan in human plasma and urine. The solvent system also served as a protein precipitation reagent. The chromatographic separation was achieved on a CAPCELL PAK C18 column (50 mm × 2.0 mm, 5 μm, Shiseido). A mobile phase was consisted of 0.5% formic acid in water and 0.5% formic acid in acetonitrile (72:28). Detection was by positive ion electrospray tandem mass spectrometry on a Sciex API3000. The standard curves, which ranged from 5 to 2000 ng/mL in human plasma and from 0.25 to 50 μg/mL in urine, were fitted to a 1/x weighted quadratic regression model. The method proved to be accurate, specific and sensitive enough to be successfully applied to a pharmacokinetic study." @default.
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- W2079882259 date "2007-06-01" @default.
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- W2079882259 title "Determination of eprosartan in human plasma and urine by LC/MS/MS" @default.
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- W2079882259 doi "https://doi.org/10.1016/j.jchromb.2007.02.049" @default.
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