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• W2079882525 abstract "Understanding the relationship between coronary arterial blood pressure, plaque morphology and composition, and sites of fibrous cap (FC) bursting, has been the focus of many recent studies. Instability of atherosclerotic plaques, defined as the propensity for FCs to burst, has been thought to occur at places where FCs are thin and necrotic core (NC) areas are large and highly compliant. However, here we show quantitatively, using a fiber-reinforced, anisotropic and hyperelastic FE model, that FC thickness and NC size and compliance alone are limited in predicting vulnerable and high-risk plaques. We suggest that plaque instabilities primarily occur at sites of high and concentrated mechanical stresses irrespective of fibrous cap thickness or NC area and compliance. Also, limitations of imaging techniques, such as intravascular ultrasound and optical coherence tomography, for providing input into (FE) models of atherosclerosis are discussed. The proposed model can be used to predict vulnerable plaque sites and rupture risks in patients. The current study also provides a framework for future research in which three-dimensional platform and viscoelastic properties of plaque composition can be considered in time-dependent and fatigue studies." @default.
• W2079882525 created "2016-06-24" @default.
• W2079882525 creator A5010139412 @default.
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• W2079882525 date "2014-08-01" @default.
• W2079882525 modified "2023-09-27" @default.
• W2079882525 title "EFFECT OF STRESS INTENSITY FACTOR IN EVALUATION OF INSTABILITY OF ATHEROSCLEROTIC PLAQUE" @default.
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• W2079882525 doi "https://doi.org/10.1142/s0219519414500729" @default.
• W2079882525 hasPublicationYear "2014" @default.
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