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• W2079883203 abstract "The voltage gated Na channels play vital role in action potential waveform shaping and propagation. We have shown earlier that the duration and amplitude of a prolonged depolarization alter all the steady state and kinetic parameters of rNa(v)1.2a voltage gated Na channel in a pseudo-oscillatory fashion. In the present study, we show that the Hodgkin-Huxley voltage and time dependent rate constants of activation (alpha(m) and beta(m)) and fast inactivation (alpha(h) and beta(h)), obtained from the analyses of Na currents and steady state activation and inactivation plots, following application of prepulses in both slow (1-100s) and fast (100-1000ms) ranges, vary with the duration of a prepulse in a pseudo-oscillatory manner. Using these Hodgkin-Huxley kinetic parameters in simulation, the excitability and firing pattern of a model neuron are shown to vary in a history dependent periodic fashion." @default.
• W2079883203 created "2016-06-24" @default.
• W2079883203 creator A5006520474 @default.
• W2079883203 creator A5030830335 @default.
• W2079883203 date "2007-08-01" @default.
• W2079883203 modified "2023-09-27" @default.
• W2079883203 title "Periodicity in Na+ channel properties alters excitability of a model neuron" @default.
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• W2079883203 doi "https://doi.org/10.1016/j.bbrc.2007.05.185" @default.
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