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- W2079884921 abstract "Behavioural and vegetative changes following intravenous injections of 10–100 mg/kg dibutyryl cyclic 3',5'-adenosine monophosphate (dibutyryl cyclic AMP) were investigated in conscious dogs. Dibutyryl cyclic AMP produced recurrent vomiting, defaecation culminating in diarrhea and hypoactivity. The intensity of these three symptoms, evaluated by a rating scale, was dose-dependent. Vomiting and defaecation induced by dibutyryl cyclic AMP (30 mg/kg) were prevented effectively by prior subcutaneous administration of 0.05 mg/kg haloperidol. Defaecation was also prevented by prior administration of atropine (1 mg/kg, s.c.), but vomiting was not. After repeated vomiting and defaecation the dogs usually fell into “sedation” which was not modified by haloperidol but intensified by atropine pretreatment." @default.
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- W2079884921 date "1976-09-01" @default.
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- W2079884921 title "Behavioural and vegetative effects of dibutyryl cyclic amp on conscious dogs" @default.
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- W2079884921 doi "https://doi.org/10.1016/0028-3908(76)90110-6" @default.
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