FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079886579> ?p ?o ?g. }

• W2079886579 endingPage "953" @default.
• W2079886579 startingPage "947" @default.
• W2079886579 abstract "The importance of nitric oxide (NO) for CBF variations associated with arterial carbon dioxide changes was investigated in halothane-anesthetized rats by using an inhibitor of nitric oxide synthase, NG-nitro-L-arginine (NOLAG). CBF was measured by intracarotid injection of 133Xe. In normocapnia, intracarotid infusion of 1.5, or 7.5, or 30 mg/kg NOLAG induced a dose-dependent increase of arterial blood pressure and a decrease of normocapnic CBF from 85 +/- 10 to 78 +/- 6, 64 +/- 5, and 52 +/- 5 ml 100 g-1 min-1, respectively. This effect lasted for at least 2 h. Raising PaCO2 from a control level of 40 to 68 mm Hg increased CBF to 230 +/- 27 ml 100 g-1 min-1, corresponding to a percentage CBF response (CO2 reactivity) of 3.7 +/- 0.6%/mm Hg PaCO2 in saline-treated rats. NOLAG attenuated this reactivity by 32, 49, and 51% at the three-dose levels. Hypercapnia combined with angiotensin to raise blood pressure to the same level as the highest dose of NOLAG did not affect the CBF response to hypercapnia. L-Arginine significantly prevented the effect of NOLAG on normocapnic CBF as well as blood pressure and also abolished its inhibitory effect on hypercapnic CBF. D-Arginine had no such effect. Decreasing PaCO2 to 20 mm Hg reduced control CBF to 46 +/- 3 ml 100 g-1 min-1 with no further reduction after NOLAG. Furthermore, NOLAG did not change the percentage CBF response to an extracellular acidosis induced by acetazolamide (50 mg/kg).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2079886579 created "2016-06-24" @default.
• W2079886579 creator A5034291249 @default.
• W2079886579 creator A5049536373 @default.
• W2079886579 creator A5079637316 @default.
• W2079886579 date "1992-11-01" @default.
• W2079886579 modified "2023-10-15" @default.
• W2079886579 title "Effect of Nitric Oxide Blockade by <i>N</i>^G-Nitro-l-Arginine on Cerebral Blood Flow Response to Changes in Carbon Dioxide Tension" @default.
• W2079886579 cites W1581310431 @default.
• W2079886579 cites W1804406719 @default.
• W2079886579 cites W1892184508 @default.
• W2079886579 cites W1946153048 @default.
• W2079886579 cites W1965481360 @default.
• W2079886579 cites W1966322594 @default.
• W2079886579 cites W1968940355 @default.
• W2079886579 cites W1971005608 @default.
• W2079886579 cites W1971938856 @default.
• W2079886579 cites W1982683838 @default.
• W2079886579 cites W1990065551 @default.
• W2079886579 cites W1994950364 @default.
• W2079886579 cites W2002019101 @default.
• W2079886579 cites W2007737411 @default.
• W2079886579 cites W2012665291 @default.
• W2079886579 cites W2024862570 @default.
• W2079886579 cites W2025664264 @default.
• W2079886579 cites W2030040645 @default.
• W2079886579 cites W2034307263 @default.
• W2079886579 cites W2037131185 @default.
• W2079886579 cites W2038857987 @default.
• W2079886579 cites W2048635427 @default.
• W2079886579 cites W2051031104 @default.
• W2079886579 cites W2051106202 @default.
• W2079886579 cites W2057396284 @default.
• W2079886579 cites W2059467695 @default.
• W2079886579 cites W2060243949 @default.
• W2079886579 cites W2075068003 @default.
• W2079886579 cites W2083565776 @default.
• W2079886579 cites W2083841106 @default.
• W2079886579 cites W2088683988 @default.
• W2079886579 cites W2092145002 @default.
• W2079886579 cites W2095104103 @default.
• W2079886579 cites W2116166509 @default.
• W2079886579 cites W2120660758 @default.
• W2079886579 cites W2133612643 @default.
• W2079886579 cites W2153889396 @default.
• W2079886579 cites W2318243423 @default.
• W2079886579 cites W2413715682 @default.
• W2079886579 cites W627342482 @default.
• W2079886579 doi "https://doi.org/10.1038/jcbfm.1992.131" @default.
• W2079886579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1400648" @default.
• W2079886579 hasPublicationYear "1992" @default.
• W2079886579 type Work @default.
• W2079886579 sameAs 2079886579 @default.
• W2079886579 citedByCount "151" @default.
• W2079886579 countsByYear W20798865792012 @default.
• W2079886579 countsByYear W20798865792014 @default.
• W2079886579 countsByYear W20798865792015 @default.
• W2079886579 countsByYear W20798865792016 @default.
• W2079886579 countsByYear W20798865792017 @default.
• W2079886579 countsByYear W20798865792018 @default.
• W2079886579 countsByYear W20798865792019 @default.
• W2079886579 countsByYear W20798865792020 @default.
• W2079886579 countsByYear W20798865792022 @default.
• W2079886579 crossrefType "journal-article" @default.
• W2079886579 hasAuthorship W2079886579A5034291249 @default.
• W2079886579 hasAuthorship W2079886579A5049536373 @default.
• W2079886579 hasAuthorship W2079886579A5079637316 @default.
• W2079886579 hasConcept C134018914 @default.
• W2079886579 hasConcept C157767197 @default.
• W2079886579 hasConcept C178790620 @default.
• W2079886579 hasConcept C185592680 @default.
• W2079886579 hasConcept C2777037550 @default.
• W2079886579 hasConcept C2777397205 @default.
• W2079886579 hasConcept C2777405951 @default.
• W2079886579 hasConcept C2777622882 @default.
• W2079886579 hasConcept C2778010969 @default.
• W2079886579 hasConcept C2778553927 @default.
• W2079886579 hasConcept C2781382112 @default.
• W2079886579 hasConcept C2908937200 @default.
• W2079886579 hasConcept C42219234 @default.
• W2079886579 hasConcept C519581460 @default.
• W2079886579 hasConcept C71924100 @default.
• W2079886579 hasConcept C84393581 @default.
• W2079886579 hasConceptScore W2079886579C134018914 @default.
• W2079886579 hasConceptScore W2079886579C157767197 @default.
• W2079886579 hasConceptScore W2079886579C178790620 @default.
• W2079886579 hasConceptScore W2079886579C185592680 @default.
• W2079886579 hasConceptScore W2079886579C2777037550 @default.
• W2079886579 hasConceptScore W2079886579C2777397205 @default.
• W2079886579 hasConceptScore W2079886579C2777405951 @default.
• W2079886579 hasConceptScore W2079886579C2777622882 @default.
• W2079886579 hasConceptScore W2079886579C2778010969 @default.
• W2079886579 hasConceptScore W2079886579C2778553927 @default.
• W2079886579 hasConceptScore W2079886579C2781382112 @default.
• W2079886579 hasConceptScore W2079886579C2908937200 @default.
• W2079886579 hasConceptScore W2079886579C42219234 @default.
• W2079886579 hasConceptScore W2079886579C519581460 @default.
• W2079886579 hasConceptScore W2079886579C71924100 @default.

• next