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- W2079887543 abstract "A modified tissue-type plasminogen activator (t-PA), YM866, which is characterized by its relatively long half-life, was studied in a rat model of myocardial infarction and compared with alteplase, a native-type t-PA. Acute myocardial infarction was induced by thrombotic occlusion of the left coronary artery using a combination of green light irradiation (540 nm) and intravenous injection of rose bengal (a photosensitizer dye). Infarct size measurements were done 24 h after irradiation. YM866 at doses of 0.25 and 1 mg/kg was administered by i.v. bolus injection, whereas alteplase at a dose of 7.5 mg/kg was administered by 10% i.v. bolus followed immediately by 90% i.v. infusion for 60 min. When these agents were administered 3 min after elevation of the ST-segment on a lead-II electrocardiogram, infarct size in the YM866 1 mg/kg group (22.3 ± 4.2%, mean ± SEM) and alteplase-treatment group (23.7 ± 5.9%) was significantly smaller than infarct size in the control group (41.7 ± 3.3%, P < 0.05 each). When these agents were administered 10 min after ST-segment elevation (both), only YM866 showed an infarct size-limiting effect (21.3 ± 5.3%, P < 0.05). i.v. bolus injection of YM866 showed equivalent infarct-limiting effect to i.v. bolus plus i.v. infusion administration of alteplase. Bolus injection of YM866 also appeared more useful than the bolus plus infusion of alteplase in terms of the therapeutic time window. These findings suggest YM866 to be an effective and easily administered thrombolytic agent. Drug Dev. Res. 51:200–205, 2000. © 2001 Wiley-Liss, Inc." @default.
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- W2079887543 date "2000-11-01" @default.
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- W2079887543 title "Reduction in myocardial infarct size by YM866, a modified tissue-type plasminogen activator, after coronary artery thrombotic occlusion in rats" @default.
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- W2079887543 doi "https://doi.org/10.1002/1098-2299(200011)51:3<200::aid-ddr10>3.0.co;2-z" @default.
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