FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079891083> ?p ?o ?g. }

• W2079891083 endingPage "5339" @default.
• W2079891083 startingPage "5329" @default.
• W2079891083 abstract "Cilia are complex organelles involved in sensory perception and fluid or cell movement. They are constructed through a highly conserved process called intraflagellar transport (IFT). Mutations in IFT genes, such as Tg737, result in severe developmental defects and disease. In the case of the Tg737orpk mutants, these pathological alterations include cystic kidney disease, biliary and pancreatic duct abnormalities, skeletal patterning defects, and hydrocephalus. Here, we explore the connection between cilia dysfunction and the development of hydrocephalus by using the Tg737orpk mutants. Our analysis indicates that cilia on cells of the brain ventricles of Tg737orpk mutant mice are severely malformed. On the ependymal cells, these defects lead to disorganized beating and impaired cerebrospinal fluid (CSF) movement. However, the loss of the cilia beat and CSF flow is not the initiating factor, as the pathology is present prior to the development of motile cilia on these cells and CSF flow is not impaired at early stages of the disease. Rather, our results suggest that loss of cilia leads to altered function of the choroid plexus epithelum, as evidenced by elevated intracellular cAMP levels and increased chloride concentration in the CSF. These data suggest that cilia function is necessary for regulating ion transport and CSF production, as well as for CSF flow through the ventricles." @default.
• W2079891083 created "2016-06-24" @default.
• W2079891083 creator A5004449948 @default.
• W2079891083 creator A5016175624 @default.
• W2079891083 creator A5017412830 @default.
• W2079891083 creator A5032282486 @default.
• W2079891083 creator A5043158762 @default.
• W2079891083 creator A5051124292 @default.
• W2079891083 creator A5059199281 @default.
• W2079891083 creator A5069099621 @default.
• W2079891083 creator A5089595851 @default.
• W2079891083 date "2005-12-01" @default.
• W2079891083 modified "2023-10-10" @default.
• W2079891083 title "Dysfunctional cilia lead to altered ependyma and choroid plexus function,and result in the formation of hydrocephalus" @default.
• W2079891083 cites W1499624551 @default.
• W2079891083 cites W1793556073 @default.
• W2079891083 cites W1817515827 @default.
• W2079891083 cites W1986175901 @default.
• W2079891083 cites W1990997051 @default.
• W2079891083 cites W1999751103 @default.
• W2079891083 cites W2001624793 @default.
• W2079891083 cites W2013681980 @default.
• W2079891083 cites W2038682505 @default.
• W2079891083 cites W2048813357 @default.
• W2079891083 cites W2052013435 @default.
• W2079891083 cites W2081765246 @default.
• W2079891083 cites W2082765963 @default.
• W2079891083 cites W2094838109 @default.
• W2079891083 cites W2095869636 @default.
• W2079891083 cites W2115687133 @default.
• W2079891083 cites W2120455375 @default.
• W2079891083 cites W2123700457 @default.
• W2079891083 cites W2131959123 @default.
• W2079891083 cites W2137043350 @default.
• W2079891083 cites W2143287752 @default.
• W2079891083 cites W2146041633 @default.
• W2079891083 cites W2152188117 @default.
• W2079891083 cites W2153120377 @default.
• W2079891083 cites W2155463318 @default.
• W2079891083 cites W2159467374 @default.
• W2079891083 cites W2162726549 @default.
• W2079891083 cites W2178934203 @default.
• W2079891083 cites W2190720904 @default.
• W2079891083 cites W2315026115 @default.
• W2079891083 cites W4244866895 @default.
• W2079891083 cites W4246673719 @default.
• W2079891083 doi "https://doi.org/10.1242/dev.02153" @default.
• W2079891083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16284123" @default.
• W2079891083 hasPublicationYear "2005" @default.
• W2079891083 type Work @default.
• W2079891083 sameAs 2079891083 @default.
• W2079891083 citedByCount "318" @default.
• W2079891083 countsByYear W20798910832012 @default.
• W2079891083 countsByYear W20798910832013 @default.
• W2079891083 countsByYear W20798910832014 @default.
• W2079891083 countsByYear W20798910832015 @default.
• W2079891083 countsByYear W20798910832016 @default.
• W2079891083 countsByYear W20798910832017 @default.
• W2079891083 countsByYear W20798910832018 @default.
• W2079891083 countsByYear W20798910832019 @default.
• W2079891083 countsByYear W20798910832020 @default.
• W2079891083 countsByYear W20798910832021 @default.
• W2079891083 countsByYear W20798910832022 @default.
• W2079891083 countsByYear W20798910832023 @default.
• W2079891083 crossrefType "journal-article" @default.
• W2079891083 hasAuthorship W2079891083A5004449948 @default.
• W2079891083 hasAuthorship W2079891083A5016175624 @default.
• W2079891083 hasAuthorship W2079891083A5017412830 @default.
• W2079891083 hasAuthorship W2079891083A5032282486 @default.
• W2079891083 hasAuthorship W2079891083A5043158762 @default.
• W2079891083 hasAuthorship W2079891083A5051124292 @default.
• W2079891083 hasAuthorship W2079891083A5059199281 @default.
• W2079891083 hasAuthorship W2079891083A5069099621 @default.
• W2079891083 hasAuthorship W2079891083A5089595851 @default.
• W2079891083 hasBestOaLocation W20798910831 @default.
• W2079891083 hasConcept C100094513 @default.
• W2079891083 hasConcept C104317684 @default.
• W2079891083 hasConcept C105702510 @default.
• W2079891083 hasConcept C126838900 @default.
• W2079891083 hasConcept C134018914 @default.
• W2079891083 hasConcept C142724271 @default.
• W2079891083 hasConcept C143065580 @default.
• W2079891083 hasConcept C169760540 @default.
• W2079891083 hasConcept C195267511 @default.
• W2079891083 hasConcept C2776538271 @default.
• W2079891083 hasConcept C2776663378 @default.
• W2079891083 hasConcept C2778134817 @default.
• W2079891083 hasConcept C2779651940 @default.
• W2079891083 hasConcept C2909073510 @default.
• W2079891083 hasConcept C2910722709 @default.
• W2079891083 hasConcept C37590093 @default.
• W2079891083 hasConcept C529278444 @default.
• W2079891083 hasConcept C54355233 @default.
• W2079891083 hasConcept C71924100 @default.
• W2079891083 hasConcept C86803240 @default.
• W2079891083 hasConcept C95444343 @default.
• W2079891083 hasConceptScore W2079891083C100094513 @default.
• W2079891083 hasConceptScore W2079891083C104317684 @default.

• next