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- W2079891133 abstract "Mayumi Ito and her colleagues show that during skin wounding in mice, melanocyte stem cells in the hair follicle are induced by melanocortin 1 receptor (Mc1r) signaling to migrate towards the epidermis and differentiate into mature pigment-producing cells. This mechanism allows for protection of the healing skin from ultraviolet light–induced damage. During wound healing, stem cells provide functional mature cells to meet acute demands for tissue regeneration1. Simultaneously, the tissue must maintain a pool of stem cells to sustain its future regeneration capability. However, how these requirements are balanced in response to injury is unknown. Here we demonstrate that after wounding or ultraviolet type B irradiation, melanocyte stem cells (McSCs) in the hair follicle2 exit the stem cell niche before their initial cell division, potentially depleting the pool of these cells. We also found that McSCs migrate to the epidermis in a melanocortin 1 receptor (Mc1r)-dependent manner and differentiate into functional epidermal melanocytes, providing a pigmented protective barrier against ultraviolet irradiation over the damaged skin. These findings provide an example in which stem cell differentiation due to injury takes precedence over stem cell maintenance and show the potential for developing therapies for skin pigmentation disorders by manipulating McSCs." @default.
- W2079891133 created "2016-06-24" @default.
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- W2079891133 date "2013-06-09" @default.
- W2079891133 modified "2023-10-12" @default.
- W2079891133 title "Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling" @default.
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- W2079891133 doi "https://doi.org/10.1038/nm.3194" @default.
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