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• W2079891149 endingPage "210" @default.
• W2079891149 startingPage "203" @default.
• W2079891149 abstract "We have experimentally tested whether the MRKTKLAPT sequence in FMDV 3D protein (residues 16 to 24) can act as a nuclear localization signal (NLS). Mutants with substitutions in two basic residues within this sequence, K18E and K20E, were generated. A decreased nuclear localization was observed in transiently expressed 3D and its precursor 3CD, suggesting a role of K18 and K20 in nuclear targeting. Fusion of MRKTKLAPT to the green fluorescence protein (GFP) increased the nuclear localization of GFP, which was not observed when GFP was fused to the 3D mutated sequences. These results indicate that the sequence MRKTKLAPT can be functionally considered as a NLS. When introduced in a FMDV full length RNA replacements K18E and K20E led to production of revertant viruses that replaced the acidic residues introduced (E) by K, suggesting that the presence of lysins at positions 18 and 20 of 3D is essential for virus multiplication." @default.
• W2079891149 created "2016-06-24" @default.
• W2079891149 creator A5006841984 @default.
• W2079891149 creator A5007047178 @default.
• W2079891149 creator A5039837948 @default.
• W2079891149 date "2013-09-01" @default.
• W2079891149 modified "2023-09-26" @default.
• W2079891149 title "Characterization of a nuclear localization signal in the foot-and-mouth disease virus polymerase" @default.
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• W2079891149 doi "https://doi.org/10.1016/j.virol.2013.06.011" @default.
• W2079891149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23886493" @default.
• W2079891149 hasPublicationYear "2013" @default.
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