FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079891290> ?p ?o ?g. }

• W2079891290 endingPage "775" @default.
• W2079891290 startingPage "763" @default.
• W2079891290 abstract "The continuous shortage of organs necessitates the use of marginal organs from donors with various diseases, including arrhythmia-associated cardiac failure. One of the most frequently used anti-arrhythmic drugs is amiodarone (AM), which is given in particular in emergency situations. Apart from its anti-arrhythmic actions, AM provides anti-oxidative properties in cardiomyocytes. Thus, we were interested in whether AM donor pretreatment affects the organ quality and function of livers procured for preservation and transplantation. Donor rats were pretreated with AM (5 mg/kg of body weight) 10 minutes before flush-out of the liver with a cold (4 degrees C) histidine-tryptophan-ketoglutarate solution (n = 8). Livers were then stored for 24 hours at 4 degrees C before ex situ reperfusion with a 37 degrees C Krebs-Henseleit solution for 60 minutes in a nonrecirculating system. At the end of reperfusion, tissue samples were taken for histology and Western blot analysis. Animals with vehicle only (0.9% NaCl) served as ischemia/reperfusion controls (n = 8). Additionally, livers of untreated animals (n = 8) not subjected to 24 hours of cold ischemia served as sham controls. AM pretreatment effectively attenuated lipid peroxidation, stress protein expression, and apoptotic cell death. This was indicated by an AM-mediated reduction of malondialdehyde, heme oxygenase-1, and caspase-3 activation. However, AM treatment also induced mitochondrial damage and hepatocellular excretory dysfunction, as indicated by a significantly increased glutamate dehydrogenase concentration in the effluate and decreased bile production. In conclusion, AM donor pretreatment exerts anti-oxidative actions in liver preservation and reperfusion. However, these protective AM actions are counteracted by an induction of mitochondrial damage and hepatocellular dysfunction. Accordingly, AM pretreatment of donors for anti-arrhythmic therapy should be performed with caution." @default.
• W2079891290 created "2016-06-24" @default.
• W2079891290 creator A5002844010 @default.
• W2079891290 creator A5009126193 @default.
• W2079891290 creator A5014577849 @default.
• W2079891290 creator A5035981422 @default.
• W2079891290 creator A5048260057 @default.
• W2079891290 creator A5051159963 @default.
• W2079891290 creator A5058509651 @default.
• W2079891290 creator A5068808230 @default.
• W2079891290 creator A5076994262 @default.
• W2079891290 creator A5088880836 @default.
• W2079891290 date "2009-06-26" @default.
• W2079891290 modified "2023-09-26" @default.
• W2079891290 title "Amiodarone pretreatment of organ donors exerts anti-oxidative protection but induces excretory dysfunction in liver preservation and reperfusion" @default.
• W2079891290 cites W114744852 @default.
• W2079891290 cites W1963729859 @default.
• W2079891290 cites W1964153329 @default.
• W2079891290 cites W1967920493 @default.
• W2079891290 cites W1978840832 @default.
• W2079891290 cites W1978854613 @default.
• W2079891290 cites W1980404619 @default.
• W2079891290 cites W1985884583 @default.
• W2079891290 cites W1989769039 @default.
• W2079891290 cites W1999082420 @default.
• W2079891290 cites W2000229204 @default.
• W2079891290 cites W2001244765 @default.
• W2079891290 cites W2003678776 @default.
• W2079891290 cites W2018363833 @default.
• W2079891290 cites W2024937208 @default.
• W2079891290 cites W2025368702 @default.
• W2079891290 cites W2025684441 @default.
• W2079891290 cites W2034431953 @default.
• W2079891290 cites W2035617137 @default.
• W2079891290 cites W2037492539 @default.
• W2079891290 cites W2042488000 @default.
• W2079891290 cites W2056793254 @default.
• W2079891290 cites W2057516062 @default.
• W2079891290 cites W2063238184 @default.
• W2079891290 cites W2067748170 @default.
• W2079891290 cites W2070745350 @default.
• W2079891290 cites W2094922589 @default.
• W2079891290 cites W2103391985 @default.
• W2079891290 cites W2106292206 @default.
• W2079891290 cites W2108928593 @default.
• W2079891290 cites W2121403293 @default.
• W2079891290 cites W2123101265 @default.
• W2079891290 cites W2139341781 @default.
• W2079891290 cites W2155462764 @default.
• W2079891290 cites W2169526588 @default.
• W2079891290 cites W2326579808 @default.
• W2079891290 cites W4239987246 @default.
• W2079891290 cites W4245133251 @default.
• W2079891290 cites W99979893 @default.
• W2079891290 doi "https://doi.org/10.1002/lt.21757" @default.
• W2079891290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19562710" @default.
• W2079891290 hasPublicationYear "2009" @default.
• W2079891290 type Work @default.
• W2079891290 sameAs 2079891290 @default.
• W2079891290 citedByCount "9" @default.
• W2079891290 countsByYear W20798912902012 @default.
• W2079891290 countsByYear W20798912902015 @default.
• W2079891290 countsByYear W20798912902020 @default.
• W2079891290 crossrefType "journal-article" @default.
• W2079891290 hasAuthorship W2079891290A5002844010 @default.
• W2079891290 hasAuthorship W2079891290A5009126193 @default.
• W2079891290 hasAuthorship W2079891290A5014577849 @default.
• W2079891290 hasAuthorship W2079891290A5035981422 @default.
• W2079891290 hasAuthorship W2079891290A5048260057 @default.
• W2079891290 hasAuthorship W2079891290A5051159963 @default.
• W2079891290 hasAuthorship W2079891290A5058509651 @default.
• W2079891290 hasAuthorship W2079891290A5068808230 @default.
• W2079891290 hasAuthorship W2079891290A5076994262 @default.
• W2079891290 hasAuthorship W2079891290A5088880836 @default.
• W2079891290 hasBestOaLocation W20798912901 @default.
• W2079891290 hasConcept C113278225 @default.
• W2079891290 hasConcept C126322002 @default.
• W2079891290 hasConcept C134018914 @default.
• W2079891290 hasConcept C144027150 @default.
• W2079891290 hasConcept C16527932 @default.
• W2079891290 hasConcept C185592680 @default.
• W2079891290 hasConcept C2776151105 @default.
• W2079891290 hasConcept C2778401633 @default.
• W2079891290 hasConcept C2779609443 @default.
• W2079891290 hasConcept C2780114680 @default.
• W2079891290 hasConcept C2780829032 @default.
• W2079891290 hasConcept C2911091166 @default.
• W2079891290 hasConcept C2988529969 @default.
• W2079891290 hasConcept C541997718 @default.
• W2079891290 hasConcept C55493867 @default.
• W2079891290 hasConcept C57600042 @default.
• W2079891290 hasConcept C71924100 @default.
• W2079891290 hasConcept C86803240 @default.
• W2079891290 hasConcept C98274493 @default.
• W2079891290 hasConceptScore W2079891290C113278225 @default.
• W2079891290 hasConceptScore W2079891290C126322002 @default.
• W2079891290 hasConceptScore W2079891290C134018914 @default.
• W2079891290 hasConceptScore W2079891290C144027150 @default.

• next