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- W2079891322 abstract "Abstract It is postulated that the Australia-antigen particle of hepatitis type B represents an infectious agent different from viruses described so far. It is assumed that it consists of a very small amount of R.N.A.-enzyme complex (virion) with an amount of host protein far in excess of the protein coat of most other viruses. These host proteins include various pre-existing structures of the liver cell. Acute type-B viral hepatitis is regarded as a restricted immunological response to the proteins in the complete B-antigen particle. It is presumed that, if there is a hepatitic antecedent of chronic liver disease, it will be B-antigen-positive hepatitis. Such chronic liver disease may be the result of one of two processes: (1) continued restricted immune reactions to the virion or, more probably, to the protein of the whole B-antigen particle, with infectivity which persists because of the presence of the virion and with a characteristic distribution of antigen in other organs (polyarthritis and polyarteritis); (2) florid and per sisting autoimmune reaction to specific host components of broken-down B-antigen particles, occurring predominantly in females, in the absence of the virion and of infectivity, and with great variation in the clinical manifestations, depending on the character of the antigenic components of the particle fragment and the organ localisation of immune complexes. The nature of the autoimmunogen in the particle may determine whether a chronic aggressive hepatitis, primary biliary cirrhosis, or an overlapping syndrome develops." @default.
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- W2079891322 date "1972-05-01" @default.
- W2079891322 modified "2023-09-27" @default.
- W2079891322 title "RELATION BETWEEN AUSTRALIA ANTIGEN AND AUTOIMMUNE HEPATITIS" @default.
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- W2079891322 doi "https://doi.org/10.1016/s0140-6736(72)91379-7" @default.
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