FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079892204> ?p ?o ?g. }

• W2079892204 endingPage "e84155" @default.
• W2079892204 startingPage "e84155" @default.
• W2079892204 abstract "The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development are well documented. While recent studies have shed some light on the importance of the stroma during renal development, many of the signals generated in the stroma, the genetic pathways and interaction networks involving the stroma are yet to be identified. Our previous studies demonstrate that retinoids are crucial for branching of the ureteric bud and for patterning of the cortical stroma. In the present study we demonstrate that autocrine retinoic acid (RA) signaling in stromal cells is critical for their survival and patterning, and show that Extracellular matrix 1, Ecm1, a gene that in humans causes irritable bowel syndrome and lipoid proteinosis, is a novel RA-regulated target in the developing kidney, which is secreted from the cortical stromal cells surrounding the cap mesenchyme and ureteric bud. Our studies suggest that Ecm1 is required in the ureteric bud for regulating the distribution of Ret which is normally restricted to the tips, as inhibition of Ecm1 results in an expanded domain of Ret expression and reduced numbers of branches. We propose a model in which retinoid signaling in the stroma activates expression of Ecm1, which in turn down-regulates Ret expression in the ureteric bud cleft, where bifurcation normally occurs and normal branching progresses." @default.
• W2079892204 created "2016-06-24" @default.
• W2079892204 creator A5007966733 @default.
• W2079892204 creator A5026506282 @default.
• W2079892204 creator A5032708398 @default.
• W2079892204 creator A5040120471 @default.
• W2079892204 creator A5051163835 @default.
• W2079892204 creator A5051475582 @default.
• W2079892204 creator A5052944648 @default.
• W2079892204 creator A5068129374 @default.
• W2079892204 creator A5085792074 @default.
• W2079892204 creator A5085800142 @default.
• W2079892204 date "2013-12-31" @default.
• W2079892204 modified "2023-10-06" @default.
• W2079892204 title "Stromal Protein Ecm1 Regulates Ureteric Bud Patterning and Branching" @default.
• W2079892204 cites W1519512220 @default.
• W2079892204 cites W1592260247 @default.
• W2079892204 cites W1596549154 @default.
• W2079892204 cites W1873268238 @default.
• W2079892204 cites W1972838071 @default.
• W2079892204 cites W1992900650 @default.
• W2079892204 cites W1996832260 @default.
• W2079892204 cites W2000707439 @default.
• W2079892204 cites W2007281432 @default.
• W2079892204 cites W2012595595 @default.
• W2079892204 cites W2013024656 @default.
• W2079892204 cites W2014379657 @default.
• W2079892204 cites W2027221684 @default.
• W2079892204 cites W2033672171 @default.
• W2079892204 cites W2035049713 @default.
• W2079892204 cites W2039309643 @default.
• W2079892204 cites W2044161168 @default.
• W2079892204 cites W2052119406 @default.
• W2079892204 cites W2061665233 @default.
• W2079892204 cites W2066311287 @default.
• W2079892204 cites W2067296617 @default.
• W2079892204 cites W2074680887 @default.
• W2079892204 cites W2084176144 @default.
• W2079892204 cites W2087580238 @default.
• W2079892204 cites W2088449391 @default.
• W2079892204 cites W2104648259 @default.
• W2079892204 cites W2115415083 @default.
• W2079892204 cites W2117287510 @default.
• W2079892204 cites W2117358667 @default.
• W2079892204 cites W2118717572 @default.
• W2079892204 cites W2143508168 @default.
• W2079892204 cites W2145130892 @default.
• W2079892204 cites W2151341838 @default.
• W2079892204 cites W2160029256 @default.
• W2079892204 cites W2167589429 @default.
• W2079892204 cites W2169829977 @default.
• W2079892204 cites W2419008308 @default.
• W2079892204 cites W4241756135 @default.
• W2079892204 doi "https://doi.org/10.1371/journal.pone.0084155" @default.
• W2079892204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3877229" @default.
• W2079892204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24391906" @default.
• W2079892204 hasPublicationYear "2013" @default.
• W2079892204 type Work @default.
• W2079892204 sameAs 2079892204 @default.
• W2079892204 citedByCount "33" @default.
• W2079892204 countsByYear W20798922042014 @default.
• W2079892204 countsByYear W20798922042015 @default.
• W2079892204 countsByYear W20798922042016 @default.
• W2079892204 countsByYear W20798922042017 @default.
• W2079892204 countsByYear W20798922042018 @default.
• W2079892204 countsByYear W20798922042019 @default.
• W2079892204 countsByYear W20798922042020 @default.
• W2079892204 countsByYear W20798922042021 @default.
• W2079892204 countsByYear W20798922042023 @default.
• W2079892204 crossrefType "journal-article" @default.
• W2079892204 hasAuthorship W2079892204A5007966733 @default.
• W2079892204 hasAuthorship W2079892204A5026506282 @default.
• W2079892204 hasAuthorship W2079892204A5032708398 @default.
• W2079892204 hasAuthorship W2079892204A5040120471 @default.
• W2079892204 hasAuthorship W2079892204A5051163835 @default.
• W2079892204 hasAuthorship W2079892204A5051475582 @default.
• W2079892204 hasAuthorship W2079892204A5052944648 @default.
• W2079892204 hasAuthorship W2079892204A5068129374 @default.
• W2079892204 hasAuthorship W2079892204A5085792074 @default.
• W2079892204 hasAuthorship W2079892204A5085800142 @default.
• W2079892204 hasBestOaLocation W20798922041 @default.
• W2079892204 hasConcept C104317684 @default.
• W2079892204 hasConcept C128240485 @default.
• W2079892204 hasConcept C130010870 @default.
• W2079892204 hasConcept C142724271 @default.
• W2079892204 hasConcept C145103041 @default.
• W2079892204 hasConcept C16930146 @default.
• W2079892204 hasConcept C189165786 @default.
• W2079892204 hasConcept C198826908 @default.
• W2079892204 hasConcept C203014093 @default.
• W2079892204 hasConcept C204232928 @default.
• W2079892204 hasConcept C2776340970 @default.
• W2079892204 hasConcept C2777632694 @default.
• W2079892204 hasConcept C2781121885 @default.
• W2079892204 hasConcept C502942594 @default.
• W2079892204 hasConcept C52124034 @default.
• W2079892204 hasConcept C54355233 @default.
• W2079892204 hasConcept C71924100 @default.

• next