Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079893247> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2079893247 endingPage "561" @default.
- W2079893247 startingPage "555" @default.
- W2079893247 abstract "The synthesis of four novel ligands using the amino-acid cysteine and its ethyl carboxylate derivative is described. The synthetic method involves a two-step procedure, wherein the intermediate Schiff base formed by the condensation of the amino group of the cysteine substrate and salicylaldehyde is reduced to give the target ligands. The intermediates and the final products were characterized by high resolution nuclear magnetic resonance spectroscopy. Complexation studies of the ligands with 99mTc were optimized using stannous tartrate as the reducing agent under varying reaction conditions. The complexes were characterized using standard quality control techniques such as thin layer chromatography, paper electrophoresis, and paper chromatography. Lipophilicities of the complexes were estimated by solvent extraction into chloroform. Substantial changes in net charge and lipophilicity of the 99mTc complexes were observed on substituting the carboxylic acid functionality in ligands I and II with the ethyl carboxylate groups (ligands III and IV). All the ligands formed 99mTc complexes in high yield. Whereas the complexes with ligands I and II were observed to be hydrophilic in nature and not extractable into CHCl3, ligands III and IV resulted in neutral and lipophilic 99mTc complexes. The 99mTc complex with ligand III was not stable and on storage formed a hydrophilic and nonextractable species. The biodistribution of the complexes of ligands I and II showed that they cleared predominantly through the kidneys, whereas the complexes with ligands III and IV were excreted primarily through the hepatobiliary system. No significant brain uptake was observed with the 99mTc complexes with ligands III and IV despite their favorable properties of neutrality, lipophilicity, and conversion into a hydrophilic species. These ligands offer potential for use as bifunctional chelating agents." @default.
- W2079893247 created "2016-06-24" @default.
- W2079893247 creator A5011210425 @default.
- W2079893247 creator A5022053889 @default.
- W2079893247 creator A5027895380 @default.
- W2079893247 creator A5058337709 @default.
- W2079893247 creator A5065048170 @default.
- W2079893247 creator A5066553570 @default.
- W2079893247 creator A5088582248 @default.
- W2079893247 date "1999-07-01" @default.
- W2079893247 modified "2023-09-27" @default.
- W2079893247 title "Radiochemical studies of 99mTc complexes of modified cysteine ligands and bifunctional chelating agents" @default.
- W2079893247 cites W1973470150 @default.
- W2079893247 cites W1989489478 @default.
- W2079893247 cites W2009078462 @default.
- W2079893247 cites W2017121095 @default.
- W2079893247 cites W2024380974 @default.
- W2079893247 cites W2040737214 @default.
- W2079893247 cites W2104392511 @default.
- W2079893247 doi "https://doi.org/10.1016/s0969-8051(99)00009-8" @default.
- W2079893247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10473195" @default.
- W2079893247 hasPublicationYear "1999" @default.
- W2079893247 type Work @default.
- W2079893247 sameAs 2079893247 @default.
- W2079893247 citedByCount "17" @default.
- W2079893247 countsByYear W20798932472012 @default.
- W2079893247 countsByYear W20798932472018 @default.
- W2079893247 countsByYear W20798932472020 @default.
- W2079893247 countsByYear W20798932472021 @default.
- W2079893247 countsByYear W20798932472022 @default.
- W2079893247 countsByYear W20798932472023 @default.
- W2079893247 crossrefType "journal-article" @default.
- W2079893247 hasAuthorship W2079893247A5011210425 @default.
- W2079893247 hasAuthorship W2079893247A5022053889 @default.
- W2079893247 hasAuthorship W2079893247A5027895380 @default.
- W2079893247 hasAuthorship W2079893247A5058337709 @default.
- W2079893247 hasAuthorship W2079893247A5065048170 @default.
- W2079893247 hasAuthorship W2079893247A5066553570 @default.
- W2079893247 hasAuthorship W2079893247A5088582248 @default.
- W2079893247 hasConcept C116569031 @default.
- W2079893247 hasConcept C155647269 @default.
- W2079893247 hasConcept C161790260 @default.
- W2079893247 hasConcept C170493617 @default.
- W2079893247 hasConcept C178790620 @default.
- W2079893247 hasConcept C181199279 @default.
- W2079893247 hasConcept C185592680 @default.
- W2079893247 hasConcept C197404232 @default.
- W2079893247 hasConcept C201399114 @default.
- W2079893247 hasConcept C202751555 @default.
- W2079893247 hasConcept C2776428424 @default.
- W2079893247 hasConcept C2777807558 @default.
- W2079893247 hasConcept C2778074193 @default.
- W2079893247 hasConcept C2779201268 @default.
- W2079893247 hasConcept C2779256853 @default.
- W2079893247 hasConcept C2780443040 @default.
- W2079893247 hasConcept C55493867 @default.
- W2079893247 hasConcept C71240020 @default.
- W2079893247 hasConceptScore W2079893247C116569031 @default.
- W2079893247 hasConceptScore W2079893247C155647269 @default.
- W2079893247 hasConceptScore W2079893247C161790260 @default.
- W2079893247 hasConceptScore W2079893247C170493617 @default.
- W2079893247 hasConceptScore W2079893247C178790620 @default.
- W2079893247 hasConceptScore W2079893247C181199279 @default.
- W2079893247 hasConceptScore W2079893247C185592680 @default.
- W2079893247 hasConceptScore W2079893247C197404232 @default.
- W2079893247 hasConceptScore W2079893247C201399114 @default.
- W2079893247 hasConceptScore W2079893247C202751555 @default.
- W2079893247 hasConceptScore W2079893247C2776428424 @default.
- W2079893247 hasConceptScore W2079893247C2777807558 @default.
- W2079893247 hasConceptScore W2079893247C2778074193 @default.
- W2079893247 hasConceptScore W2079893247C2779201268 @default.
- W2079893247 hasConceptScore W2079893247C2779256853 @default.
- W2079893247 hasConceptScore W2079893247C2780443040 @default.
- W2079893247 hasConceptScore W2079893247C55493867 @default.
- W2079893247 hasConceptScore W2079893247C71240020 @default.
- W2079893247 hasIssue "5" @default.
- W2079893247 hasLocation W20798932471 @default.
- W2079893247 hasLocation W20798932472 @default.
- W2079893247 hasOpenAccess W2079893247 @default.
- W2079893247 hasPrimaryLocation W20798932471 @default.
- W2079893247 hasRelatedWork W1964253971 @default.
- W2079893247 hasRelatedWork W2036155274 @default.
- W2079893247 hasRelatedWork W2060654378 @default.
- W2079893247 hasRelatedWork W2062335906 @default.
- W2079893247 hasRelatedWork W2064895892 @default.
- W2079893247 hasRelatedWork W2313979199 @default.
- W2079893247 hasRelatedWork W2415156835 @default.
- W2079893247 hasRelatedWork W2970795295 @default.
- W2079893247 hasRelatedWork W4281726504 @default.
- W2079893247 hasRelatedWork W800235602 @default.
- W2079893247 hasVolume "26" @default.
- W2079893247 isParatext "false" @default.
- W2079893247 isRetracted "false" @default.
- W2079893247 magId "2079893247" @default.
- W2079893247 workType "article" @default.