FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079896411> ?p ?o ?g. }

• W2079896411 endingPage "555" @default.
• W2079896411 startingPage "515" @default.
• W2079896411 abstract "Neurons have complex and often extensively elongated processes. This unique cell morphology raises the problem of how remote neuronal territories are replenished with proteins. For a long time, axonal and presynaptic proteins were thought to be exclusively synthesized in the cell body, which delivered them to peripheral sites by axoplasmic transport. Despite this early belief, protein has been shown to be synthesized in axons and nerve terminals, substantially alleviating the trophic burden of the perikaryon. This observation raised the question of the cellular origin of the peripheral RNAs involved in protein synthesis. The synthesis of these RNAs was initially attributed to the neuron soma almost by default. However, experimental data and theoretical considerations support the alternative view that axonal and presynaptic RNAs are also transcribed in the flanking glial cells and transferred to the axon domain of mature neurons. Altogether, these data suggest that axons and nerve terminals are served by a distinct gene expression system largely independent of the neuron cell body. Such a local system would allow the neuron periphery to respond promptly to environmental stimuli. This view has the theoretical merit of extending to axons and nerve terminals the marginalized concept of a glial supply of RNA (and protein) to the neuron cell body. Most long-term plastic changes requiring de novo gene expression occur in these domains, notably in presynaptic endings, despite their intrinsic lack of transcriptional capacity. This review enlightens novel perspectives on the biology and pathobiology of the neuron by critically reviewing these issues." @default.
• W2079896411 created "2016-06-24" @default.
• W2079896411 creator A5011524285 @default.
• W2079896411 creator A5058589260 @default.
• W2079896411 creator A5066501556 @default.
• W2079896411 creator A5069400647 @default.
• W2079896411 creator A5085543559 @default.
• W2079896411 creator A5090947498 @default.
• W2079896411 date "2008-04-01" @default.
• W2079896411 modified "2023-09-23" @default.
• W2079896411 title "Local Gene Expression in Axons and Nerve Endings: The Glia-Neuron Unit" @default.
• W2079896411 cites W1483900451 @default.
• W2079896411 cites W1490426518 @default.
• W2079896411 cites W150915971 @default.
• W2079896411 cites W1509229887 @default.
• W2079896411 cites W1533802536 @default.
• W2079896411 cites W1538641465 @default.
• W2079896411 cites W1542171240 @default.
• W2079896411 cites W1547693568 @default.
• W2079896411 cites W1569125973 @default.
• W2079896411 cites W1608513258 @default.
• W2079896411 cites W1632755291 @default.
• W2079896411 cites W1636792448 @default.
• W2079896411 cites W1678534475 @default.
• W2079896411 cites W1728943698 @default.
• W2079896411 cites W1803762742 @default.
• W2079896411 cites W1834805773 @default.
• W2079896411 cites W1939071643 @default.
• W2079896411 cites W1944821277 @default.
• W2079896411 cites W1958333154 @default.
• W2079896411 cites W1962426462 @default.
• W2079896411 cites W1963741570 @default.
• W2079896411 cites W1964077512 @default.
• W2079896411 cites W1964505864 @default.
• W2079896411 cites W1965292526 @default.
• W2079896411 cites W1966356114 @default.
• W2079896411 cites W1967385673 @default.
• W2079896411 cites W1968477477 @default.
• W2079896411 cites W1969080564 @default.
• W2079896411 cites W1969390950 @default.
• W2079896411 cites W1969629251 @default.
• W2079896411 cites W1970060945 @default.
• W2079896411 cites W1970356391 @default.
• W2079896411 cites W1970403529 @default.
• W2079896411 cites W1970409943 @default.
• W2079896411 cites W1971030028 @default.
• W2079896411 cites W1971399511 @default.
• W2079896411 cites W1972038062 @default.
• W2079896411 cites W1972208445 @default.
• W2079896411 cites W1973023260 @default.
• W2079896411 cites W1973059738 @default.
• W2079896411 cites W1973561010 @default.
• W2079896411 cites W1973872974 @default.
• W2079896411 cites W1973947673 @default.
• W2079896411 cites W1974326501 @default.
• W2079896411 cites W1974404501 @default.
• W2079896411 cites W1974617672 @default.
• W2079896411 cites W1976330729 @default.
• W2079896411 cites W1977431945 @default.
• W2079896411 cites W1977815398 @default.
• W2079896411 cites W1978048593 @default.
• W2079896411 cites W1978074271 @default.
• W2079896411 cites W1978547782 @default.
• W2079896411 cites W1978836458 @default.
• W2079896411 cites W1978918651 @default.
• W2079896411 cites W1979496428 @default.
• W2079896411 cites W1980019523 @default.
• W2079896411 cites W1980075211 @default.
• W2079896411 cites W1980916224 @default.
• W2079896411 cites W1981121658 @default.
• W2079896411 cites W1981232919 @default.
• W2079896411 cites W1981840233 @default.
• W2079896411 cites W1982240728 @default.
• W2079896411 cites W1982270181 @default.
• W2079896411 cites W1982691688 @default.
• W2079896411 cites W1983020058 @default.
• W2079896411 cites W1983097628 @default.
• W2079896411 cites W1983765259 @default.
• W2079896411 cites W1983871952 @default.
• W2079896411 cites W1984447158 @default.
• W2079896411 cites W1984590208 @default.
• W2079896411 cites W1984627595 @default.
• W2079896411 cites W1985440054 @default.
• W2079896411 cites W1986097868 @default.
• W2079896411 cites W1986920325 @default.
• W2079896411 cites W1986942336 @default.
• W2079896411 cites W1987030209 @default.
• W2079896411 cites W1987877227 @default.
• W2079896411 cites W1988461462 @default.
• W2079896411 cites W1988665236 @default.
• W2079896411 cites W1989177998 @default.
• W2079896411 cites W1989695985 @default.
• W2079896411 cites W1990296640 @default.
• W2079896411 cites W1990413163 @default.
• W2079896411 cites W1990676652 @default.
• W2079896411 cites W1991392398 @default.
• W2079896411 cites W1992087788 @default.
• W2079896411 cites W1992745035 @default.

• next