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- W2079901450 abstract "Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is a protein that is involved in highly proliferative growth states ie, embryogenesis and carcinogenesis. By virtue of its binding to a key growth regulatory component, IGF II leader-3 mRNA, IMP3 controls essential growth regulatory aspects including RNA binding, trafficking and stabilization, cellular maturation and migration. Recently, IMP3's potential to function as an oncofetal protein has been recognized along with the potential for IMP3 expression to serve as an indicator of eminent malignant transformation. Notably, IMP3 expression in human cervical dysplastic lesions showed a positive correlation with concurrent cervical cancer while high grade dysplasias without associated cancers were IMP3 negative." @default.
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- W2079901450 date "2012-09-01" @default.
- W2079901450 modified "2023-10-05" @default.
- W2079901450 title "Poster 58: IMP3: A Putative Protein Signaling Eminent Malignant Transformation" @default.
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- W2079901450 doi "https://doi.org/10.1016/j.joms.2012.06.114" @default.
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