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• W2079905587 abstract "The integrin beta6 has been shown to promote invasion and experimental metastasis by oral squamous cell carcinoma (SCC). In this study, we demonstrate that the expression of beta6 by oral SCC9 cells increased activation of the UPA --> MMP3 --> MMP9 pathway. We also demonstrate that the deposition of fibronectin and tenascin-C matrices by SCC9beta6 cells and peritumor fibroblast cocultures is counter-regulated by the UPA --> MMP3 --> MMP9 pathway. Suppression of individual components of this pathway increased the deposition of fibronectin, but decreased tenascin-C matrix assembly by the cocultures. When the SCC9beta6/PTF cocultures were incubated with TGFbeta1, the deposition of fibronectin and tenascin-C as well as the activation of MMP3 and MMP9 was increased. These results indicate that MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral SCC." @default.
• W2079905587 created "2016-06-24" @default.
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• W2079905587 date "2004-04-01" @default.
• W2079905587 modified "2023-10-02" @default.
• W2079905587 title "Matrix metalloproteinases and TGFβ1 modulate oral tumor cell matrix" @default.
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• W2079905587 doi "https://doi.org/10.1016/j.bbrc.2004.02.143" @default.
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