Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079908295> ?p ?o ?g. }
- W2079908295 endingPage "8039" @default.
- W2079908295 startingPage "8032" @default.
- W2079908295 abstract "A series of acridine derivatives were synthesised and their in vitro antimalarial activity was evaluated against one chloroquine-susceptible strain (3D7) and three chloroquine-resistant strains (W2, Bre1 and FCR3) of Plasmodium falciparum. Structure–activity relationship showed that two positives charges as well as 6-chloro and 2-methoxy substituents on the acridine ring were required to exert a good antimalarial activity. The best compounds possessing these features inhibited the growth of the chloroquine-susceptible strain with an IC50 ⩽ 0.07 μM, close to that of chloroquine itself, and that of the three chloroquine-resistant strains better than chloroquine with IC50 ⩽ 0.3 μM. These acridine derivatives inhibited the formation of β-hematin, suggesting that, like CQ, they act on the haem crystallization process. Finally, in vitro cytotoxicity was also evaluated upon human KB cells, which showed that one of them 9-(6-ammonioethylamino)-6-chloro-2-methoxyacridinium dichloride 1 displayed a promising antimalarial activity in vitro with a quite good selectivity index versus mammalian cell on the CQ-susceptible strain and promising selectivity on other strains." @default.
- W2079908295 created "2016-06-24" @default.
- W2079908295 creator A5015167376 @default.
- W2079908295 creator A5020030977 @default.
- W2079908295 creator A5051053812 @default.
- W2079908295 creator A5052651595 @default.
- W2079908295 creator A5062862335 @default.
- W2079908295 creator A5063829698 @default.
- W2079908295 creator A5078098543 @default.
- W2079908295 creator A5078754448 @default.
- W2079908295 creator A5079362938 @default.
- W2079908295 date "2009-12-01" @default.
- W2079908295 modified "2023-10-18" @default.
- W2079908295 title "Antimalarial acridines: Synthesis, in vitro activity against P. falciparum and interaction with hematin" @default.
- W2079908295 cites W1976906219 @default.
- W2079908295 cites W1988605236 @default.
- W2079908295 cites W1995064146 @default.
- W2079908295 cites W1998835931 @default.
- W2079908295 cites W1998945480 @default.
- W2079908295 cites W2001124223 @default.
- W2079908295 cites W2012834867 @default.
- W2079908295 cites W2017140568 @default.
- W2079908295 cites W2017878528 @default.
- W2079908295 cites W2031675782 @default.
- W2079908295 cites W2045031843 @default.
- W2079908295 cites W2045133086 @default.
- W2079908295 cites W2047742004 @default.
- W2079908295 cites W2053342497 @default.
- W2079908295 cites W2057832900 @default.
- W2079908295 cites W2070968159 @default.
- W2079908295 cites W2072349085 @default.
- W2079908295 cites W2075955447 @default.
- W2079908295 cites W2077097901 @default.
- W2079908295 cites W2077341686 @default.
- W2079908295 cites W2087424544 @default.
- W2079908295 cites W2091021359 @default.
- W2079908295 cites W2092604097 @default.
- W2079908295 cites W2092645997 @default.
- W2079908295 cites W2103016383 @default.
- W2079908295 cites W2124709443 @default.
- W2079908295 cites W2129930577 @default.
- W2079908295 cites W2131308200 @default.
- W2079908295 cites W2135547910 @default.
- W2079908295 cites W2139474242 @default.
- W2079908295 cites W2149218017 @default.
- W2079908295 cites W2158538948 @default.
- W2079908295 cites W79387094 @default.
- W2079908295 doi "https://doi.org/10.1016/j.bmc.2009.10.005" @default.
- W2079908295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19879150" @default.
- W2079908295 hasPublicationYear "2009" @default.
- W2079908295 type Work @default.
- W2079908295 sameAs 2079908295 @default.
- W2079908295 citedByCount "31" @default.
- W2079908295 countsByYear W20799082952012 @default.
- W2079908295 countsByYear W20799082952013 @default.
- W2079908295 countsByYear W20799082952014 @default.
- W2079908295 countsByYear W20799082952015 @default.
- W2079908295 countsByYear W20799082952016 @default.
- W2079908295 countsByYear W20799082952017 @default.
- W2079908295 countsByYear W20799082952018 @default.
- W2079908295 countsByYear W20799082952019 @default.
- W2079908295 countsByYear W20799082952020 @default.
- W2079908295 countsByYear W20799082952021 @default.
- W2079908295 countsByYear W20799082952022 @default.
- W2079908295 countsByYear W20799082952023 @default.
- W2079908295 crossrefType "journal-article" @default.
- W2079908295 hasAuthorship W2079908295A5015167376 @default.
- W2079908295 hasAuthorship W2079908295A5020030977 @default.
- W2079908295 hasAuthorship W2079908295A5051053812 @default.
- W2079908295 hasAuthorship W2079908295A5052651595 @default.
- W2079908295 hasAuthorship W2079908295A5062862335 @default.
- W2079908295 hasAuthorship W2079908295A5063829698 @default.
- W2079908295 hasAuthorship W2079908295A5078098543 @default.
- W2079908295 hasAuthorship W2079908295A5078754448 @default.
- W2079908295 hasAuthorship W2079908295A5079362938 @default.
- W2079908295 hasConcept C105702510 @default.
- W2079908295 hasConcept C109316439 @default.
- W2079908295 hasConcept C118792377 @default.
- W2079908295 hasConcept C161790260 @default.
- W2079908295 hasConcept C178790620 @default.
- W2079908295 hasConcept C185592680 @default.
- W2079908295 hasConcept C202751555 @default.
- W2079908295 hasConcept C203014093 @default.
- W2079908295 hasConcept C2776924795 @default.
- W2079908295 hasConcept C2777425658 @default.
- W2079908295 hasConcept C2777752497 @default.
- W2079908295 hasConcept C2778022156 @default.
- W2079908295 hasConcept C2778048844 @default.
- W2079908295 hasConcept C2778371730 @default.
- W2079908295 hasConcept C2910410043 @default.
- W2079908295 hasConcept C55493867 @default.
- W2079908295 hasConcept C71240020 @default.
- W2079908295 hasConcept C86803240 @default.
- W2079908295 hasConceptScore W2079908295C105702510 @default.
- W2079908295 hasConceptScore W2079908295C109316439 @default.
- W2079908295 hasConceptScore W2079908295C118792377 @default.
- W2079908295 hasConceptScore W2079908295C161790260 @default.
- W2079908295 hasConceptScore W2079908295C178790620 @default.