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- W2079921911 abstract "Quantitative data have been obtained on the inhibitory effects of cycloheximide on 14C-leucine incorporation into the proteins of a variety of rat tissues. Of fourteen organ systems examined, all were significantly affected under the test condition with 0.5 mg/kg of the drug given i.p., i.v. or intragastrically. As little as 0.05 mg/kg i.p. of cycloheximide affected certain organs; most tissues had some inhibition at 0.25 mg/kg with increasing effects up to 4 mg/kg, which was the maximum dose tested. When the labelled amino acid was injected 0.5 hr after 0.5 mg/kg of cycloheximide and the rats were sacrificed 4 hr later, maximum inhibition of leucine incorporation was noted. The inhibition began to decrease within 3 hr after cycloheximide administration and disappeared at 6–12 hr. Cycloheximide was found to be absorbed from the stomach in the pylorus-ligated rats and to exert a systemic effect on leucine incorporation. There was no consistent difference between males and females in response to cycloheximide. Acetoxycycloheximide was more potent than cycloheximide on an equal weight basis and was more active in females than in males. Cycloheximide inhibited amino acid incorporation by liver slices and intestine segments at concentrations of 1 and 10 μg/ml respectively." @default.
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- W2079921911 date "1969-08-01" @default.
- W2079921911 modified "2023-09-26" @default.
- W2079921911 title "Quantitative aspects of cycloheximide inhibition of amino acid incorporation" @default.
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- W2079921911 doi "https://doi.org/10.1016/0006-2952(69)90287-1" @default.
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