FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079954414> ?p ?o ?g. }

• W2079954414 endingPage "62" @default.
• W2079954414 startingPage "55" @default.
• W2079954414 abstract "We show that LPA1 (lysophosphatidic acid receptor-1) is constitutively localized in the nucleus of mammalian cells. LPA1 also traffics from cell membranes to the nucleus in response to LPA (lysophosphatidic acid). Several lines of evidence suggest an important role for cell-matrix interaction in regulating the constitutive nuclear localization of LPA1. First, the RGDS peptide, which blocks cell matrix-induced integrin clustering and cytoskeletal rearrangement, reduced the number of cells containing LPA1 in the nucleus. Secondly, a higher proportion of cells contained nuclear LPA1 when adhesion on fibronectin-coated glass was compared with adherence to polylysine-coated glass. Thirdly, pre-treatment of cells with the Rho kinase inhibitor (Y27632) or the myosin light chain kinase inhibitor (ML9) reduced the number of cells containing nuclear LPA1. The addition of LPA and/or Ki16425 (which binds to LPA1) to isolated nuclei containing LPA1 induced the phosphorylation of several proteins with molecular masses of 34, 32, 14 and 11 kDa. These findings demonstrate that trafficking of LPA1 to the nucleus is influenced by cell-matrix interactions and that nuclear LPA1 may be involved in regulating intranuclear protein phosphorylation and signalling." @default.
• W2079954414 created "2016-06-24" @default.
• W2079954414 creator A5001429190 @default.
• W2079954414 creator A5017816363 @default.
• W2079954414 creator A5023834954 @default.
• W2079954414 creator A5035375282 @default.
• W2079954414 creator A5039380491 @default.
• W2079954414 creator A5052741677 @default.
• W2079954414 creator A5060561968 @default.
• W2079954414 creator A5071553204 @default.
• W2079954414 date "2006-07-27" @default.
• W2079954414 modified "2023-09-29" @default.
• W2079954414 title "Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells" @default.
• W2079954414 cites W1870053867 @default.
• W2079954414 cites W1971838938 @default.
• W2079954414 cites W1985095445 @default.
• W2079954414 cites W1987142592 @default.
• W2079954414 cites W1992289979 @default.
• W2079954414 cites W1994715500 @default.
• W2079954414 cites W1999108824 @default.
• W2079954414 cites W2025191509 @default.
• W2079954414 cites W2041069947 @default.
• W2079954414 cites W2047693390 @default.
• W2079954414 cites W2055062107 @default.
• W2079954414 cites W2068006705 @default.
• W2079954414 cites W2068432279 @default.
• W2079954414 cites W2079220485 @default.
• W2079954414 cites W2081954647 @default.
• W2079954414 cites W2082775864 @default.
• W2079954414 cites W2098615703 @default.
• W2079954414 cites W2102073119 @default.
• W2079954414 cites W2118914136 @default.
• W2079954414 cites W2142500412 @default.
• W2079954414 cites W2143141083 @default.
• W2079954414 cites W2154457032 @default.
• W2079954414 cites W2158067174 @default.
• W2079954414 cites W2160189137 @default.
• W2079954414 cites W2161142786 @default.
• W2079954414 doi "https://doi.org/10.1042/bj20060155" @default.
• W2079954414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1525019" @default.
• W2079954414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16716145" @default.
• W2079954414 hasPublicationYear "2006" @default.
• W2079954414 type Work @default.
• W2079954414 sameAs 2079954414 @default.
• W2079954414 citedByCount "35" @default.
• W2079954414 countsByYear W20799544142012 @default.
• W2079954414 countsByYear W20799544142013 @default.
• W2079954414 countsByYear W20799544142014 @default.
• W2079954414 countsByYear W20799544142016 @default.
• W2079954414 countsByYear W20799544142017 @default.
• W2079954414 countsByYear W20799544142018 @default.
• W2079954414 countsByYear W20799544142019 @default.
• W2079954414 countsByYear W20799544142020 @default.
• W2079954414 countsByYear W20799544142021 @default.
• W2079954414 countsByYear W20799544142022 @default.
• W2079954414 countsByYear W20799544142023 @default.
• W2079954414 crossrefType "journal-article" @default.
• W2079954414 hasAuthorship W2079954414A5001429190 @default.
• W2079954414 hasAuthorship W2079954414A5017816363 @default.
• W2079954414 hasAuthorship W2079954414A5023834954 @default.
• W2079954414 hasAuthorship W2079954414A5035375282 @default.
• W2079954414 hasAuthorship W2079954414A5039380491 @default.
• W2079954414 hasAuthorship W2079954414A5052741677 @default.
• W2079954414 hasAuthorship W2079954414A5060561968 @default.
• W2079954414 hasAuthorship W2079954414A5071553204 @default.
• W2079954414 hasBestOaLocation W20799544142 @default.
• W2079954414 hasConcept C104317684 @default.
• W2079954414 hasConcept C105686024 @default.
• W2079954414 hasConcept C106487976 @default.
• W2079954414 hasConcept C11960822 @default.
• W2079954414 hasConcept C142669718 @default.
• W2079954414 hasConcept C1491633281 @default.
• W2079954414 hasConcept C151166631 @default.
• W2079954414 hasConcept C170493617 @default.
• W2079954414 hasConcept C185592680 @default.
• W2079954414 hasConcept C189165786 @default.
• W2079954414 hasConcept C195687474 @default.
• W2079954414 hasConcept C2776661833 @default.
• W2079954414 hasConcept C2780723820 @default.
• W2079954414 hasConcept C43617362 @default.
• W2079954414 hasConcept C55493867 @default.
• W2079954414 hasConcept C83640560 @default.
• W2079954414 hasConcept C86492073 @default.
• W2079954414 hasConcept C86803240 @default.
• W2079954414 hasConcept C95444343 @default.
• W2079954414 hasConceptScore W2079954414C104317684 @default.
• W2079954414 hasConceptScore W2079954414C105686024 @default.
• W2079954414 hasConceptScore W2079954414C106487976 @default.
• W2079954414 hasConceptScore W2079954414C11960822 @default.
• W2079954414 hasConceptScore W2079954414C142669718 @default.
• W2079954414 hasConceptScore W2079954414C1491633281 @default.
• W2079954414 hasConceptScore W2079954414C151166631 @default.
• W2079954414 hasConceptScore W2079954414C170493617 @default.
• W2079954414 hasConceptScore W2079954414C185592680 @default.
• W2079954414 hasConceptScore W2079954414C189165786 @default.
• W2079954414 hasConceptScore W2079954414C195687474 @default.
• W2079954414 hasConceptScore W2079954414C2776661833 @default.
• W2079954414 hasConceptScore W2079954414C2780723820 @default.

• next