FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079959213> ?p ?o ?g. }

• W2079959213 endingPage "111" @default.
• W2079959213 startingPage "111" @default.
• W2079959213 abstract "The future role of personalized medicine in the treatment of glioblastoma multiforme Jing Li1,2, Chunhui Di1,2, Austin K Mattox1,2, Linda Wu1,2, D Cory Adamson1,2,3,41Preston Robert Tisch Brain Tumor Center, Duke Medical Center, Durham, North Carolina, USA; 2Department of Surgery (Neurosurgery), Duke Medical Center, Durham, North Carolina, USA; 3Department of Neurobiology, Duke Medical Center, Durham, North Carolina, USA; 4Neurosurgery Section, Durham VA Medical Center, Durham, North Carolina, USAAbstract: Glioblastoma multiforme (GBM) remains one of the most malignant primary central nervous system tumors. Personalized therapeutic approaches have not become standard of care for GBM, but science is fast approaching this goal. GBM’s heterogeneous genomic landscape and resistance to radiotherapy and chemotherapy make this tumor one of the most challenging to treat. Recent advances in genome-wide studies and genetic profiling show that there is unlikely to be a single genetic or cellular event that can be effectively targeted in all patients. Instead, future therapies will likely require personalization for each patient’s tumor genotype or proteomic profile. Over the past year, many investigations specifically focused simultaneously on strategies to target oncogenic pathways, angiogenesis, tumor immunology, epigenomic events, glioma stem cells (GSCs), and the highly migratory glioma cell population. Combination therapy targeting multiple pathways is becoming a fast growing area of research, and many studies put special attention on small molecule inhibitors. Because GBM is a highly vascular tumor, therapy that directs monoclonal antibodies or small molecule tyrosine kinase inhibitors toward angiogenic factors is also an area of focus for the development of new therapies. Passive, active, and adoptive immunotherapies have been explored by many studies recently, and epigenetic regulation of gene expression with microRNAs is also becoming an important area of study. GSCs can be useful targets to stop tumor recurrence and proliferation, and recent research has found key molecules that regulate GBM cell migration that can be targeted by therapy. Current standard of care for GBM remains nonspecific; however, pharmacogenomic studies are underway to pave the way for patient-specific therapies that are based on the unique aberrant pathways in individual patients. In conclusion, recent studies in GBM have found many diverse molecular targets possible for therapy. The next obstacle in treating this fatal tumor is ascertaining which molecules in each patient should be targeted and how best to target them, so that we can move our current nonspecific therapies toward the realm of personalized medicine.Keywords: GBM, oncogenomics, genetics, signaling cascades, pharmacogenomics" @default.
• W2079959213 created "2016-06-24" @default.
• W2079959213 creator A5009596244 @default.
• W2079959213 creator A5012677271 @default.
• W2079959213 creator A5067199161 @default.
• W2079959213 creator A5079134716 @default.
• W2079959213 creator A5084417480 @default.
• W2079959213 date "2010-08-01" @default.
• W2079959213 modified "2023-09-27" @default.
• W2079959213 title "The future role of personalized medicine in the treatment of glioblastoma multiforme" @default.
• W2079959213 cites W1478358416 @default.
• W2079959213 cites W1480346895 @default.
• W2079959213 cites W1533555842 @default.
• W2079959213 cites W1556788203 @default.
• W2079959213 cites W1558094668 @default.
• W2079959213 cites W1588322702 @default.
• W2079959213 cites W1588880146 @default.
• W2079959213 cites W159772189 @default.
• W2079959213 cites W1600228347 @default.
• W2079959213 cites W1651982135 @default.
• W2079959213 cites W1790847442 @default.
• W2079959213 cites W1869160040 @default.
• W2079959213 cites W1911965864 @default.
• W2079959213 cites W192600146 @default.
• W2079959213 cites W1934298787 @default.
• W2079959213 cites W1938158279 @default.
• W2079959213 cites W1965641124 @default.
• W2079959213 cites W1966803171 @default.
• W2079959213 cites W1970219318 @default.
• W2079959213 cites W1970418706 @default.
• W2079959213 cites W1971674000 @default.
• W2079959213 cites W1972218893 @default.
• W2079959213 cites W1972380031 @default.
• W2079959213 cites W1974234783 @default.
• W2079959213 cites W1975061879 @default.
• W2079959213 cites W1977087883 @default.
• W2079959213 cites W1977199192 @default.
• W2079959213 cites W1983502543 @default.
• W2079959213 cites W1985911340 @default.
• W2079959213 cites W1987045589 @default.
• W2079959213 cites W1988040203 @default.
• W2079959213 cites W1988986134 @default.
• W2079959213 cites W1992859930 @default.
• W2079959213 cites W2000089945 @default.
• W2079959213 cites W2001660159 @default.
• W2079959213 cites W2003135941 @default.
• W2079959213 cites W2007276180 @default.
• W2079959213 cites W2009063639 @default.
• W2079959213 cites W2009669110 @default.
• W2079959213 cites W2012819315 @default.
• W2079959213 cites W2014994637 @default.
• W2079959213 cites W2018776569 @default.
• W2079959213 cites W2020579237 @default.
• W2079959213 cites W2020891498 @default.
• W2079959213 cites W2021454803 @default.
• W2079959213 cites W2024514018 @default.
• W2079959213 cites W2026375824 @default.
• W2079959213 cites W2026726491 @default.
• W2079959213 cites W2027388325 @default.
• W2079959213 cites W2032090704 @default.
• W2079959213 cites W2032944619 @default.
• W2079959213 cites W2033128037 @default.
• W2079959213 cites W2035021866 @default.
• W2079959213 cites W2038796494 @default.
• W2079959213 cites W2041546528 @default.
• W2079959213 cites W2042949684 @default.
• W2079959213 cites W2044555111 @default.
• W2079959213 cites W2046542779 @default.
• W2079959213 cites W2049214772 @default.
• W2079959213 cites W2054035764 @default.
• W2079959213 cites W2058332573 @default.
• W2079959213 cites W2061554178 @default.
• W2079959213 cites W2062723225 @default.
• W2079959213 cites W2063825866 @default.
• W2079959213 cites W2064214863 @default.
• W2079959213 cites W2064316340 @default.
• W2079959213 cites W2065162738 @default.
• W2079959213 cites W2068345721 @default.
• W2079959213 cites W2068427129 @default.
• W2079959213 cites W2068480808 @default.
• W2079959213 cites W2069294039 @default.
• W2079959213 cites W2071083851 @default.
• W2079959213 cites W2071893342 @default.
• W2079959213 cites W2072228651 @default.
• W2079959213 cites W2079487111 @default.
• W2079959213 cites W2080449761 @default.
• W2079959213 cites W2080518113 @default.
• W2079959213 cites W2082475821 @default.
• W2079959213 cites W2084050866 @default.
• W2079959213 cites W2087128761 @default.
• W2079959213 cites W2087186976 @default.
• W2079959213 cites W2088925558 @default.
• W2079959213 cites W2090577904 @default.
• W2079959213 cites W2092950531 @default.
• W2079959213 cites W2093783077 @default.
• W2079959213 cites W2096136751 @default.
• W2079959213 cites W2096287682 @default.
• W2079959213 cites W2096947122 @default.

• next