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- W2079959987 endingPage "e0122184" @default.
- W2079959987 startingPage "e0122184" @default.
- W2079959987 abstract "The mechanistic study of glaucoma pathogenesis has shifted to seeking to understand the effects of immune responses on retinal ganglion cell damage and protection. Cytokines mediate the biological effects of the immune system, and our previous study revealed an imbalance of T-helper (Th) 1-derived and Th2-derived cytokines in the serum of patients with glaucoma. In this study, we collected irises from normal individuals and patients with primary open-angle closure (POAG) or chronic angle-closure glaucoma (CACG). We used real-time polymerase chain reaction (PCR) to measure the expression of Th1 (interleukin (IL)-2, interferon-gamma (IFN-γ)), Th2 (IL-4, IL-6, IL-10), and Th3 (transforming growth factor-beta (TGF-β)) cytokines. We then performed immunohistochemical staining to characterize the localization of the upregulated cytokines in iris cryosections. We observed an upward trend in the expression of IL-2 and IFN-γ and a downward trend in IL-6 expression in the iris of POAG and CACG patients. Expression of TGF-β also increased. Immunohistochemistry revealed that IL-2 expression in POAG and CACG patients was localized in the anterior surface of the blood vessel wall in the stroma of the iris, in the cytoplasm of some cells, in the anterior epithelium, and in the posterior pigment epithelium. These findings indicate that immune status differed between the iris tissues of POAG and CACG patients and those of normal individuals. A T-helper cytokine imbalance may modulate the immune microenvironment in glaucomatous eyes and thus influence optic neuropathy." @default.
- W2079959987 created "2016-06-24" @default.
- W2079959987 creator A5016864367 @default.
- W2079959987 creator A5035795138 @default.
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- W2079959987 creator A5052771228 @default.
- W2079959987 creator A5060002817 @default.
- W2079959987 creator A5086038672 @default.
- W2079959987 date "2015-03-26" @default.
- W2079959987 modified "2023-10-11" @default.
- W2079959987 title "T-Helper1/T-Helper2 Cytokine Imbalance in the Iris of Patients with Glaucoma" @default.
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