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- W2079961024 abstract "The aim of this study was to investigate the effects of preconditioning on amino acid neurotransmitter release, induced by hypoxia/hypoglycaemia, from rat brain cortical slices. Tissue, perfused with artificial cerebrospinal fluid (aCSF) at 37°C with zero glucose and gassed with 95% nitrogen and 5% carbon dioxide, showed a fivefold increase in glutamate release with little effect on γ-aminobutyric acid (GABA) release. Preconditioning, with three 5-min periods of hypoxia/hypoglycaemia preceding continuous hypoxia/hypoglycaemia, significantly decreased glutamate release whilst significantly elevating GABA release. These results suggest that GABA may reduce the release of glutamate and consequently decrease the neurotoxic effects of glutamate." @default.
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- W2079961024 date "2000-09-01" @default.
- W2079961024 modified "2023-10-17" @default.
- W2079961024 title "Hypoxia/Hypoglycemia-Induced Amino Acid Release Is Decreased in Vitro by Preconditioning" @default.
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- W2079961024 doi "https://doi.org/10.1006/bbrc.2000.3443" @default.
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