Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079965419> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2079965419 endingPage "416" @default.
- W2079965419 startingPage "414" @default.
- W2079965419 abstract "A step-down therapy may be more beneficial for the management of asthma than a step-up therapy.Eighty-two asthmatic patients with moderate persistent asthma were enrolled in the study and randomized into three groups. One group of patients received 400 microg/day of beclomethasone dipropionate (BDP) for 4 weeks and then 800 microg/day for another 4 weeks (step-up group). The other two groups of patients received 1,200 microg/day of BDP for 4 weeks with or without short-term oral steroid (prednisolone, 0.5 mg/day for 1 week) and then 800 microg/day for another 4 weeks (step-down group). Severe exacerbation of asthma, asthma symptoms, respiratory function and rescue use of inhaled beta(2)-agonists were monitored. If asthma was well controlled, the dose of BDP was decreased every 3 months and if asthma was exacerbated, the dose of BDP was increased until 8 months after the initial treatment.Twenty-two patients during the run-in period, 4 patients in the step-up group, 2 patients in the step-down group treated with a high dose of BDP and no patients in the step-down group with oral steroids during first 4 weeks dropped out because of severe exacerbation of asthma. Although asthma symptoms and respiratory function significantly improved 8 weeks after the therapy in all groups, more significant and prompt improvements of these parameters were observed in patients of the step-down group than in patients of the step-up group after the first 2 weeks of treatment. Furthermore, step-down therapy with short-term oral steroid resulted in the lowest maintenance doses of BDP at 8 months of the three groups.These results suggest that step-down therapy starting with a high dose of inhaled steroid and short-term oral steroid is more effective in gaining prompt control of asthma and reducing the severe exacerbation of asthma and the maintenance dose of inhaled steroids than a step-up therapy starting with a low dose of inhaled steroids in patients with moderate persistent asthma." @default.
- W2079965419 created "2016-06-24" @default.
- W2079965419 creator A5010339155 @default.
- W2079965419 creator A5028570347 @default.
- W2079965419 creator A5058878517 @default.
- W2079965419 date "2001-01-01" @default.
- W2079965419 modified "2023-09-24" @default.
- W2079965419 title "Step-Down and Step-Up Therapy in Moderate Persistent Asthma" @default.
- W2079965419 cites W2099104920 @default.
- W2079965419 cites W2331287401 @default.
- W2079965419 doi "https://doi.org/10.1159/000053774" @default.
- W2079965419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11307032" @default.
- W2079965419 hasPublicationYear "2001" @default.
- W2079965419 type Work @default.
- W2079965419 sameAs 2079965419 @default.
- W2079965419 citedByCount "6" @default.
- W2079965419 countsByYear W20799654192014 @default.
- W2079965419 countsByYear W20799654192017 @default.
- W2079965419 crossrefType "journal-article" @default.
- W2079965419 hasAuthorship W2079965419A5010339155 @default.
- W2079965419 hasAuthorship W2079965419A5028570347 @default.
- W2079965419 hasAuthorship W2079965419A5058878517 @default.
- W2079965419 hasConcept C177713679 @default.
- W2079965419 hasConcept C203014093 @default.
- W2079965419 hasConcept C2776042228 @default.
- W2079965419 hasConcept C71924100 @default.
- W2079965419 hasConceptScore W2079965419C177713679 @default.
- W2079965419 hasConceptScore W2079965419C203014093 @default.
- W2079965419 hasConceptScore W2079965419C2776042228 @default.
- W2079965419 hasConceptScore W2079965419C71924100 @default.
- W2079965419 hasIssue "1-3" @default.
- W2079965419 hasLocation W20799654191 @default.
- W2079965419 hasLocation W20799654192 @default.
- W2079965419 hasOpenAccess W2079965419 @default.
- W2079965419 hasPrimaryLocation W20799654191 @default.
- W2079965419 hasRelatedWork W116019892 @default.
- W2079965419 hasRelatedWork W1967569061 @default.
- W2079965419 hasRelatedWork W1973417040 @default.
- W2079965419 hasRelatedWork W1977726906 @default.
- W2079965419 hasRelatedWork W1984600095 @default.
- W2079965419 hasRelatedWork W2007869453 @default.
- W2079965419 hasRelatedWork W2049992228 @default.
- W2079965419 hasRelatedWork W2069371313 @default.
- W2079965419 hasRelatedWork W2071688291 @default.
- W2079965419 hasRelatedWork W2091709550 @default.
- W2079965419 hasRelatedWork W2095039325 @default.
- W2079965419 hasRelatedWork W2139441783 @default.
- W2079965419 hasRelatedWork W2166895635 @default.
- W2079965419 hasRelatedWork W2409340516 @default.
- W2079965419 hasRelatedWork W2461479797 @default.
- W2079965419 hasRelatedWork W2461650677 @default.
- W2079965419 hasRelatedWork W2464579862 @default.
- W2079965419 hasRelatedWork W2482964238 @default.
- W2079965419 hasRelatedWork W2486457003 @default.
- W2079965419 hasRelatedWork W2499218482 @default.
- W2079965419 hasVolume "124" @default.
- W2079965419 isParatext "false" @default.
- W2079965419 isRetracted "false" @default.
- W2079965419 magId "2079965419" @default.
- W2079965419 workType "article" @default.