FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079966430> ?p ?o ?g. }

• W2079966430 endingPage "218" @default.
• W2079966430 startingPage "213" @default.
• W2079966430 abstract "Liu Wei Di Huang Wan (LDW), a well-known traditional Chinese medicine, is frequently combined with other prescription or non-prescription drugs in China. This study was designed to investigate the effects of LDW on the activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO) in healthy subjects, using caffeine as a probe drug. Twelve unrelated healthy males were enrolled in a single-blind, randomized, placebo-controlled, two-phase crossover study. Placebo or LDW (12 pills, 0.2 g/pill, twice daily) was given to each participant for 14 continuous days with a wash-out period of 2 weeks. A dose of 100 mg caffeine was given afterwards to test the activities of drug-metabolizing enzymes of interest. Compared to placebo, LDW significantly induced the CYP1A2 activity, as determined by an increase in the ratio of (AFMU + 1U + 1X)/17U and the formation of 17X and 1X after taking caffeine. Interestingly, LDW significantly decreased the ratio of 17U/(17U + 17X + 1X + 1U + AFMU) and the formation of 17U (CYP2A6-mediated) (by 39.2%; 95%CI: 23.1–55.3%; P = 0.026), and decreased the ratio of AFMU/(AFMU + 1U + 1X) and the formation of AFMU (NAT2-catalized) (by 26.2%; 95%CI: 9.2–61.6%; P = 0.038), suggesting a marked inhibition of CYP2A6 and NAT2, respectively. LDW can induce CYP1A2 and suppress CYP2A6 and NAT2 activities, and affect caffeine metabolism in vivo." @default.
• W2079966430 created "2016-06-24" @default.
• W2079966430 creator A5019739018 @default.
• W2079966430 creator A5023358215 @default.
• W2079966430 creator A5027324747 @default.
• W2079966430 creator A5065610505 @default.
• W2079966430 creator A5070859641 @default.
• W2079966430 creator A5073895723 @default.
• W2079966430 creator A5079796683 @default.
• W2079966430 date "2010-10-01" @default.
• W2079966430 modified "2023-09-26" @default.
• W2079966430 title "Liu Wei Di Huang Wan, a well-known traditional Chinese medicine, induces CYP1A2 while suppressing CYP2A6 and N-acetyltransferase 2 activities in man" @default.
• W2079966430 cites W1975281817 @default.
• W2079966430 cites W1977902851 @default.
• W2079966430 cites W1993780682 @default.
• W2079966430 cites W1997995336 @default.
• W2079966430 cites W2005941511 @default.
• W2079966430 cites W2017577604 @default.
• W2079966430 cites W2033559115 @default.
• W2079966430 cites W2066099619 @default.
• W2079966430 cites W2067161976 @default.
• W2079966430 cites W2076313863 @default.
• W2079966430 cites W2079488969 @default.
• W2079966430 cites W2083084069 @default.
• W2079966430 cites W2100199295 @default.
• W2079966430 cites W2114345365 @default.
• W2079966430 cites W2334307121 @default.
• W2079966430 doi "https://doi.org/10.1016/j.jep.2010.08.011" @default.
• W2079966430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20723593" @default.
• W2079966430 hasPublicationYear "2010" @default.
• W2079966430 type Work @default.
• W2079966430 sameAs 2079966430 @default.
• W2079966430 citedByCount "16" @default.
• W2079966430 countsByYear W20799664302012 @default.
• W2079966430 countsByYear W20799664302013 @default.
• W2079966430 countsByYear W20799664302014 @default.
• W2079966430 countsByYear W20799664302015 @default.
• W2079966430 countsByYear W20799664302016 @default.
• W2079966430 countsByYear W20799664302017 @default.
• W2079966430 countsByYear W20799664302018 @default.
• W2079966430 countsByYear W20799664302019 @default.
• W2079966430 countsByYear W20799664302020 @default.
• W2079966430 countsByYear W20799664302021 @default.
• W2079966430 countsByYear W20799664302022 @default.
• W2079966430 crossrefType "journal-article" @default.
• W2079966430 hasAuthorship W2079966430A5019739018 @default.
• W2079966430 hasAuthorship W2079966430A5023358215 @default.
• W2079966430 hasAuthorship W2079966430A5027324747 @default.
• W2079966430 hasAuthorship W2079966430A5065610505 @default.
• W2079966430 hasAuthorship W2079966430A5070859641 @default.
• W2079966430 hasAuthorship W2079966430A5073895723 @default.
• W2079966430 hasAuthorship W2079966430A5079796683 @default.
• W2079966430 hasConcept C126322002 @default.
• W2079966430 hasConcept C134018914 @default.
• W2079966430 hasConcept C142724271 @default.
• W2079966430 hasConcept C185592680 @default.
• W2079966430 hasConcept C196013638 @default.
• W2079966430 hasConcept C204787440 @default.
• W2079966430 hasConcept C27081682 @default.
• W2079966430 hasConcept C2778500429 @default.
• W2079966430 hasConcept C2781245242 @default.
• W2079966430 hasConcept C526171541 @default.
• W2079966430 hasConcept C62231903 @default.
• W2079966430 hasConcept C71924100 @default.
• W2079966430 hasConcept C86745063 @default.
• W2079966430 hasConcept C98274493 @default.
• W2079966430 hasConceptScore W2079966430C126322002 @default.
• W2079966430 hasConceptScore W2079966430C134018914 @default.
• W2079966430 hasConceptScore W2079966430C142724271 @default.
• W2079966430 hasConceptScore W2079966430C185592680 @default.
• W2079966430 hasConceptScore W2079966430C196013638 @default.
• W2079966430 hasConceptScore W2079966430C204787440 @default.
• W2079966430 hasConceptScore W2079966430C27081682 @default.
• W2079966430 hasConceptScore W2079966430C2778500429 @default.
• W2079966430 hasConceptScore W2079966430C2781245242 @default.
• W2079966430 hasConceptScore W2079966430C526171541 @default.
• W2079966430 hasConceptScore W2079966430C62231903 @default.
• W2079966430 hasConceptScore W2079966430C71924100 @default.
• W2079966430 hasConceptScore W2079966430C86745063 @default.
• W2079966430 hasConceptScore W2079966430C98274493 @default.
• W2079966430 hasIssue "1" @default.
• W2079966430 hasLocation W20799664301 @default.
• W2079966430 hasLocation W20799664302 @default.
• W2079966430 hasOpenAccess W2079966430 @default.
• W2079966430 hasPrimaryLocation W20799664301 @default.
• W2079966430 hasRelatedWork W1943654482 @default.
• W2079966430 hasRelatedWork W1995322872 @default.
• W2079966430 hasRelatedWork W2000839814 @default.
• W2079966430 hasRelatedWork W2079966430 @default.
• W2079966430 hasRelatedWork W2093703284 @default.
• W2079966430 hasRelatedWork W2135881689 @default.
• W2079966430 hasRelatedWork W2288973320 @default.
• W2079966430 hasRelatedWork W2312010870 @default.
• W2079966430 hasRelatedWork W2411893516 @default.
• W2079966430 hasRelatedWork W2748952813 @default.
• W2079966430 hasVolume "132" @default.
• W2079966430 isParatext "false" @default.
• W2079966430 isRetracted "false" @default.

• next