FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079968415> ?p ?o ?g. }

• W2079968415 endingPage "65" @default.
• W2079968415 startingPage "55" @default.
• W2079968415 abstract "Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory response in the adjacent intestinal mucosa. The present studies asked whether colon epithelial cells can provide signals that are important for the initiation and amplification of an acute mucosal inflammatory response. Infection of monolayers of human colon epithelial cell lines (T84, HT29, Caco-2) with invasive strains of bacteria (Salmonella dublin, Shigella dysenteriae, Yersinia enterocolitica, Listeria monocytogenes, enteroinvasive Escherichia coli) resulted in the coordinate expression and upregulation of a specific array of four proinflammatory cytokines, IL-8, monocyte chemotactic protein-1, GM-CSF, and TNF alpha, as assessed by mRNA levels and cytokine secretion. Expression of the same cytokines was upregulated after TNF alpha or IL-1 stimulation of these cells. In contrast, cytokine gene expression was not altered after infection of colon epithelial cells with noninvasive bacteria or the noninvasive protozoan parasite, G. lamblia. Notably, none of the cell lines expressed mRNA for IL-2, IL-4, IL-5, IL-6, IL-12p40, IFN-gamma, or significant levels of IL-1 or IL-10 in response to the identical stimuli. The coordinate expression of IL-8, MCP-1, GM-CSF and TNF alpha appears to be a general property of human colon epithelial cells since an identical array of cytokines, as well as IL-6, also was expressed by freshly isolated human colon epithelial cells. Since the cytokines expressed in response to bacterial invasion or other proinflammatory agonists have a well documented role in chemotaxis and activation of inflammatory cells, colon epithelial cells appear to be programmed to provide a set of signals for the activation of the mucosal inflammatory response in the earliest phases after microbial invasion." @default.
• W2079968415 created "2016-06-24" @default.
• W2079968415 creator A5007202760 @default.
• W2079968415 creator A5031435812 @default.
• W2079968415 creator A5033189845 @default.
• W2079968415 creator A5043856063 @default.
• W2079968415 creator A5052552759 @default.
• W2079968415 creator A5081676325 @default.
• W2079968415 creator A5090690603 @default.
• W2079968415 date "1995-01-01" @default.
• W2079968415 modified "2023-10-16" @default.
• W2079968415 title "A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion." @default.
• W2079968415 cites W1482432582 @default.
• W2079968415 cites W1526805228 @default.
• W2079968415 cites W1531333401 @default.
• W2079968415 cites W1551071931 @default.
• W2079968415 cites W1574330564 @default.
• W2079968415 cites W1591046772 @default.
• W2079968415 cites W1596169348 @default.
• W2079968415 cites W1606491845 @default.
• W2079968415 cites W1623271373 @default.
• W2079968415 cites W1640670825 @default.
• W2079968415 cites W1655248452 @default.
• W2079968415 cites W1856169132 @default.
• W2079968415 cites W1865083834 @default.
• W2079968415 cites W1892094800 @default.
• W2079968415 cites W1941983524 @default.
• W2079968415 cites W1969958947 @default.
• W2079968415 cites W1976213001 @default.
• W2079968415 cites W1979519444 @default.
• W2079968415 cites W1984404339 @default.
• W2079968415 cites W1988834558 @default.
• W2079968415 cites W1997715513 @default.
• W2079968415 cites W1998647005 @default.
• W2079968415 cites W2005448612 @default.
• W2079968415 cites W2036500213 @default.
• W2079968415 cites W2044069347 @default.
• W2079968415 cites W2082649398 @default.
• W2079968415 cites W2088511697 @default.
• W2079968415 cites W2095351296 @default.
• W2079968415 cites W2096720114 @default.
• W2079968415 cites W2097994780 @default.
• W2079968415 cites W2098778559 @default.
• W2079968415 cites W2099109162 @default.
• W2079968415 cites W2102531596 @default.
• W2079968415 cites W2104064916 @default.
• W2079968415 cites W2104439753 @default.
• W2079968415 cites W2112552808 @default.
• W2079968415 cites W2112742987 @default.
• W2079968415 cites W2120253936 @default.
• W2079968415 cites W2127381835 @default.
• W2079968415 cites W2130443118 @default.
• W2079968415 cites W2139863628 @default.
• W2079968415 cites W2149897099 @default.
• W2079968415 cites W2155205499 @default.
• W2079968415 cites W2159833023 @default.
• W2079968415 cites W2162763987 @default.
• W2079968415 cites W2172466148 @default.
• W2079968415 cites W2176220887 @default.
• W2079968415 cites W2342314812 @default.
• W2079968415 cites W4290246060 @default.
• W2079968415 cites W70766684 @default.
• W2079968415 cites W75088252 @default.
• W2079968415 cites W94556339 @default.
• W2079968415 doi "https://doi.org/10.1172/jci117676" @default.
• W2079968415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/295369" @default.
• W2079968415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7814646" @default.
• W2079968415 hasPublicationYear "1995" @default.
• W2079968415 type Work @default.
• W2079968415 sameAs 2079968415 @default.
• W2079968415 citedByCount "1148" @default.
• W2079968415 countsByYear W20799684152012 @default.
• W2079968415 countsByYear W20799684152013 @default.
• W2079968415 countsByYear W20799684152014 @default.
• W2079968415 countsByYear W20799684152015 @default.
• W2079968415 countsByYear W20799684152016 @default.
• W2079968415 countsByYear W20799684152017 @default.
• W2079968415 countsByYear W20799684152018 @default.
• W2079968415 countsByYear W20799684152019 @default.
• W2079968415 countsByYear W20799684152020 @default.
• W2079968415 countsByYear W20799684152021 @default.
• W2079968415 countsByYear W20799684152022 @default.
• W2079968415 countsByYear W20799684152023 @default.
• W2079968415 crossrefType "journal-article" @default.
• W2079968415 hasAuthorship W2079968415A5007202760 @default.
• W2079968415 hasAuthorship W2079968415A5031435812 @default.
• W2079968415 hasAuthorship W2079968415A5033189845 @default.
• W2079968415 hasAuthorship W2079968415A5043856063 @default.
• W2079968415 hasAuthorship W2079968415A5052552759 @default.
• W2079968415 hasAuthorship W2079968415A5081676325 @default.
• W2079968415 hasAuthorship W2079968415A5090690603 @default.
• W2079968415 hasBestOaLocation W20799684151 @default.
• W2079968415 hasConcept C126322002 @default.
• W2079968415 hasConcept C164027704 @default.
• W2079968415 hasConcept C17991360 @default.
• W2079968415 hasConcept C203014093 @default.
• W2079968415 hasConcept C2776914184 @default.
• W2079968415 hasConcept C2778690821 @default.

• next