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- W2079977237 abstract "1 Theories linking 5-hydroxytryptamine (5-HT) with depression are briefly reviewed. The various experimental strategies adopted to investigate this relationship, examination of autopsy data, CSF metabolite data, 5-HT re-uptake patterns in human blood platelets and imipramine binding studies in human platelets, are discussed. 2 Recent studies of 5-hydroxyindole acetic acid (5-HIAA) levels in cerebrospinal fluid have revealed a linkage between low 5-HIAA levels and suicide, aggression and impulsivity. Decreases in the number of imipramine binding sites have also been found in brains of suicide victims. 3 The available data lead to the conclusion that decreased 5- hydroxytryptaminergic function may be associated with an increased risk of depression, suicide, and some types of aggression." @default.
- W2079977237 created "2016-06-24" @default.
- W2079977237 creator A5053329398 @default.
- W2079977237 creator A5053432354 @default.
- W2079977237 date "1983-06-01" @default.
- W2079977237 modified "2023-09-27" @default.
- W2079977237 title "5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology." @default.
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- W2079977237 doi "https://doi.org/10.1111/j.1365-2125.1983.tb02130.x" @default.
- W2079977237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1427648" @default.
- W2079977237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6190490" @default.
- W2079977237 hasPublicationYear "1983" @default.
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