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- W207998093 abstract "The use of plant-derived polyphenols for the management of diseases has been under debate in the last decades. Most studies have focused on the specific effects of polyphenols on particular targets, while ignoring their pleiotropic character. The multitargeted character of polyphenols, a plausible consequence of their molecular promiscuity, may suppose an opportunity to fight multifactorial diseases. Therefore, a wider perspective is urgently needed to elucidate whether their rational use as bioactive food components may be valid for the management of diseases. In this chapter, we discuss the most likely targets of polyphenols that may account for their salutary effects from a global perspective. Among these targets, the modulation of signalling and energy-sensitive pathways, oxidative stress and inflammation-related processes, mitochondrial functionality, epigenetic machinery, histone acetylation and membrane-dependent processes play central roles in polyphenols’ mechanisms of action. Sufficient evidence on polyphenols has accumulated for them to be considered a serious option for the management of non-communicable diseases, such as cancer and obesity, as well as infectious diseases. The remaining unresolved issues that must be seriously addressed are their bioavailability, metabolite detection, specific molecular targets, interactions and toxicity. The Xenohormesis hypothesis, which postulates that polyphenols are the product of plant evolutive adaptation to stress and conferee their resistance to mammals, offers a reasonable explanation to justify the beneficial and non-toxic effects of plant mixtures, but do not fully meet expectations. Hence, future research must be supported by the use of complex polypharmacology approaches and synergic studies focused on the understanding of the pleiotropic effects of polyphenols. Revisiting polyphenol mechanisms of action with the help of these techniques may allow for the improvement of human health and wellness by using intelligent nutritional intervention." @default.
- W207998093 created "2016-06-24" @default.
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- W207998093 date "2014-01-01" @default.
- W207998093 modified "2023-10-15" @default.
- W207998093 title "Molecular Promiscuity of Plant Polyphenols in the Management of Age-Related Diseases: Far Beyond Their Antioxidant Properties" @default.
- W207998093 cites W1671762088 @default.
- W207998093 cites W1857137828 @default.
- W207998093 cites W1963904011 @default.
- W207998093 cites W1964853932 @default.
- W207998093 cites W1965936120 @default.
- W207998093 cites W1968302053 @default.
- W207998093 cites W1968742921 @default.
- W207998093 cites W1971062590 @default.
- W207998093 cites W1972129435 @default.
- W207998093 cites W1973220859 @default.
- W207998093 cites W1974033843 @default.
- W207998093 cites W1976206793 @default.
- W207998093 cites W1977267072 @default.
- W207998093 cites W1979223116 @default.
- W207998093 cites W1981343290 @default.
- W207998093 cites W1983279602 @default.
- W207998093 cites W1984697868 @default.
- W207998093 cites W1986115299 @default.
- W207998093 cites W1987370786 @default.
- W207998093 cites W1988511889 @default.
- W207998093 cites W1990791836 @default.
- W207998093 cites W1991605705 @default.
- W207998093 cites W1991774590 @default.
- W207998093 cites W1991854067 @default.
- W207998093 cites W1993132387 @default.
- W207998093 cites W1995339117 @default.
- W207998093 cites W1997453506 @default.
- W207998093 cites W1997542501 @default.
- W207998093 cites W1999793522 @default.
- W207998093 cites W2000180786 @default.
- W207998093 cites W2001335097 @default.
- W207998093 cites W2003701537 @default.
- W207998093 cites W2004625762 @default.
- W207998093 cites W2008314179 @default.
- W207998093 cites W2008748583 @default.
- W207998093 cites W2010625981 @default.
- W207998093 cites W2014620242 @default.
- W207998093 cites W2016562927 @default.
- W207998093 cites W2016752484 @default.
- W207998093 cites W2021552230 @default.
- W207998093 cites W2022359747 @default.
- W207998093 cites W2024798740 @default.
- W207998093 cites W2027922456 @default.
- W207998093 cites W2030433334 @default.
- W207998093 cites W2031298315 @default.
- W207998093 cites W2033591223 @default.
- W207998093 cites W2033896075 @default.
- W207998093 cites W2033898921 @default.
- W207998093 cites W2034825007 @default.
- W207998093 cites W2036658349 @default.
- W207998093 cites W2037998901 @default.
- W207998093 cites W2044542888 @default.
- W207998093 cites W2048760199 @default.
- W207998093 cites W2053213876 @default.
- W207998093 cites W2055780054 @default.
- W207998093 cites W2058198559 @default.
- W207998093 cites W2059336872 @default.
- W207998093 cites W2059642778 @default.
- W207998093 cites W2059780959 @default.
- W207998093 cites W2060893427 @default.
- W207998093 cites W2062944717 @default.
- W207998093 cites W2064428412 @default.
- W207998093 cites W2067049036 @default.
- W207998093 cites W2069948617 @default.
- W207998093 cites W2072187010 @default.
- W207998093 cites W2074017133 @default.
- W207998093 cites W2074317596 @default.
- W207998093 cites W2078265076 @default.
- W207998093 cites W2079862480 @default.
- W207998093 cites W2080860848 @default.
- W207998093 cites W2082168464 @default.
- W207998093 cites W2083498728 @default.
- W207998093 cites W2086070469 @default.
- W207998093 cites W2087736738 @default.
- W207998093 cites W2088381487 @default.
- W207998093 cites W2095077363 @default.
- W207998093 cites W2098400092 @default.
- W207998093 cites W2098864721 @default.
- W207998093 cites W2099084108 @default.
- W207998093 cites W2100846969 @default.
- W207998093 cites W2103659405 @default.
- W207998093 cites W2110890911 @default.
- W207998093 cites W2113313289 @default.
- W207998093 cites W2117696416 @default.
- W207998093 cites W2117833492 @default.
- W207998093 cites W2124463172 @default.