FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080031009> ?p ?o ?g. }

• W2080031009 endingPage "14" @default.
• W2080031009 startingPage "1" @default.
• W2080031009 abstract "Macrophages serve as a depot for HIV type-1 (HIV-1) in the central nervous system. To efficiently target macrophages, we developed nanocarriers for potential brain delivery of activated nucleoside reverse transcriptase inhibitors (NRTIs) called nano-NRTIs.Nanogel carriers consisting of poly(ethylene glycol) (PEG)- or Pluronic-polyethylenimine (PEI) biodegradable networks, star PEG-PEI or poly(amidoamine) dendrimer-PEI-PEG dendritic networks, as well as nanogels decorated with brain-targeting peptide molecules, specifically binding to the apolipoprotein E receptor, were synthesized and evaluated. Nano-NRTIs were obtained by mixing aqueous solutions of zidovudine 5'-triphosphate or didanosine 5'-triphosphate and nanocarriers, followed by freeze-drying. Intracellular accumulation, cytotoxicity and antiviral activity of nano-NRTIs were monitored in monocyte-derived macrophages (MDMs). HIV-1 viral activity in infected MDMs was measured by a reverse transcriptase activity assay following treatment with nano-NRTIs. Mitochondrial DNA depletion in MDMs and human HepG2 cells was assessed by quantitative PCR.Nanogels were efficiently captured by MDMs and demonstrated low cytotoxicity, and no antiviral activity without drugs. All nano-NRTIs demonstrated high efficacy of HIV-1 inhibition at drug levels as low as 1 μmol/l, representing a 4.9- to 14-fold decrease in 90% effective drug concentrations as compared with NRTIs, whereas 50% cytotoxicity effects started at 200× higher concentrations. Nano-NRTIs with a core-shell structure and decorated with brain-targeting peptides displayed the highest antiviral efficacy. Mitochondrial DNA depletion, a major cause of NRTI neurotoxicity, was reduced threefold compared with NRTIs at application of selected nano-NRTIs.Nano-NRTIs demonstrated a promising antiviral efficacy against HIV-1 in MDMs and showed strong potential as nanocarriers for delivery of antiviral drugs to macrophages harbouring in the brain." @default.
• W2080031009 created "2016-06-24" @default.
• W2080031009 creator A5003163966 @default.
• W2080031009 creator A5018484393 @default.
• W2080031009 creator A5019263208 @default.
• W2080031009 creator A5026111070 @default.
• W2080031009 creator A5028937829 @default.
• W2080031009 date "2010-10-01" @default.
• W2080031009 modified "2023-10-06" @default.
• W2080031009 title "Nano-NRTIs: Efficient Inhibitors of HIV Type-1 in Macrophages with a Reduced Mitochondrial Toxicity" @default.
• W2080031009 cites W1480548185 @default.
• W2080031009 cites W1797402756 @default.
• W2080031009 cites W1967304559 @default.
• W2080031009 cites W1972348350 @default.
• W2080031009 cites W1974687989 @default.
• W2080031009 cites W1975258429 @default.
• W2080031009 cites W1982396030 @default.
• W2080031009 cites W1985021981 @default.
• W2080031009 cites W2006707825 @default.
• W2080031009 cites W2008146806 @default.
• W2080031009 cites W2014370099 @default.
• W2080031009 cites W2030903461 @default.
• W2080031009 cites W2039796373 @default.
• W2080031009 cites W2051609383 @default.
• W2080031009 cites W2058033003 @default.
• W2080031009 cites W2061863138 @default.
• W2080031009 cites W2065082591 @default.
• W2080031009 cites W2066081065 @default.
• W2080031009 cites W2073344259 @default.
• W2080031009 cites W2073558493 @default.
• W2080031009 cites W2074478455 @default.
• W2080031009 cites W2078104479 @default.
• W2080031009 cites W2078912182 @default.
• W2080031009 cites W2080482668 @default.
• W2080031009 cites W2082211638 @default.
• W2080031009 cites W2083306904 @default.
• W2080031009 cites W2089750884 @default.
• W2080031009 cites W2090866080 @default.
• W2080031009 cites W2096887401 @default.
• W2080031009 cites W2111806003 @default.
• W2080031009 cites W2126590617 @default.
• W2080031009 cites W2129568931 @default.
• W2080031009 cites W2150918607 @default.
• W2080031009 cites W2156670379 @default.
• W2080031009 cites W2162838846 @default.
• W2080031009 cites W2163148038 @default.
• W2080031009 cites W2163588120 @default.
• W2080031009 cites W2170245954 @default.
• W2080031009 cites W2335061539 @default.
• W2080031009 doi "https://doi.org/10.3851/imp1680" @default.
• W2080031009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3032393" @default.
• W2080031009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21045256" @default.
• W2080031009 hasPublicationYear "2010" @default.
• W2080031009 type Work @default.
• W2080031009 sameAs 2080031009 @default.
• W2080031009 citedByCount "44" @default.
• W2080031009 countsByYear W20800310092012 @default.
• W2080031009 countsByYear W20800310092013 @default.
• W2080031009 countsByYear W20800310092014 @default.
• W2080031009 countsByYear W20800310092015 @default.
• W2080031009 countsByYear W20800310092016 @default.
• W2080031009 countsByYear W20800310092017 @default.
• W2080031009 countsByYear W20800310092018 @default.
• W2080031009 countsByYear W20800310092019 @default.
• W2080031009 countsByYear W20800310092020 @default.
• W2080031009 countsByYear W20800310092021 @default.
• W2080031009 countsByYear W20800310092022 @default.
• W2080031009 countsByYear W20800310092023 @default.
• W2080031009 crossrefType "journal-article" @default.
• W2080031009 hasAuthorship W2080031009A5003163966 @default.
• W2080031009 hasAuthorship W2080031009A5018484393 @default.
• W2080031009 hasAuthorship W2080031009A5019263208 @default.
• W2080031009 hasAuthorship W2080031009A5026111070 @default.
• W2080031009 hasAuthorship W2080031009A5028937829 @default.
• W2080031009 hasBestOaLocation W20800310091 @default.
• W2080031009 hasConcept C104317684 @default.
• W2080031009 hasConcept C109316439 @default.
• W2080031009 hasConcept C134424308 @default.
• W2080031009 hasConcept C156719811 @default.
• W2080031009 hasConcept C159047783 @default.
• W2080031009 hasConcept C178790620 @default.
• W2080031009 hasConcept C18150654 @default.
• W2080031009 hasConcept C185592680 @default.
• W2080031009 hasConcept C202751555 @default.
• W2080031009 hasConcept C2522874641 @default.
• W2080031009 hasConcept C2777351918 @default.
• W2080031009 hasConcept C2777447569 @default.
• W2080031009 hasConcept C2779820397 @default.
• W2080031009 hasConcept C2779889181 @default.
• W2080031009 hasConcept C2780035454 @default.
• W2080031009 hasConcept C2780216070 @default.
• W2080031009 hasConcept C2780727368 @default.
• W2080031009 hasConcept C2780866839 @default.
• W2080031009 hasConcept C2909970146 @default.
• W2080031009 hasConcept C55493867 @default.
• W2080031009 hasConcept C67705224 @default.
• W2080031009 hasConcept C86803240 @default.
• W2080031009 hasConcept C98274493 @default.

• next