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• W2080045055 abstract "The swelling‐activated outwardly rectifying Cl − current (I Cl(swell) ) recorded in T 8 4 human intestinal cells was completely blocked by 10 μM tamoxifen, while 300 μM Cd 2+ had no effect. A ClC‐2‐like, inwardly rectifying Cl − current was activated after strong hyperpolarization in T 8 4 cells. This current was completely inhibited by 300 μM Cd 2+ , unaffected by 10 μM tamoxifen, and its magnitude increased slightly in response to cell swelling under hyposmotic conditions. However, the swelling‐dependent modulation occurred only after prior activation by hyperpolarizing voltages. T 8 4 cells behaved initially close to perfect osmometers in response to changes in external osmolalities between +20 and ‐30 %. The cells underwent full regulatory volume decrease (RVD) within 16 min when exposed to 30 or 10 % hyposmotic shocks. Pharmacological tools were used to determine the anionic pathway(s) involved in RVD in T 8 4 cells. Tamoxifen (10 μM), 1,9‐dideoxyforskolin (DDFSK; 100 μM) and 4,4′‐diisothiocyanatostilbene‐2,2′‐disulphonic acid (DIDS; 100 μM) blocked RVD while 300 μM Cd 2+ had no effect upon RVD following a 30 % hyposmotic shock. The RVD response was similarly unaffected by Cd 2+ when cells were exposed to a smaller (10 %) hyposmotic shock. In conclusion, these data show that the anionic pathway primarily activated by cell swelling and relevant to RVD in T 8 4 cells is the tamoxifen‐, DDFSK‐ and DIDS‐sensitive I Cl(swell) and not the hyperpolarization‐activated, Cd 2+ ‐sensitive Cl − current associated with the ClC‐2 Cl − channel." @default.
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• W2080045055 date "1998-08-01" @default.
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• W2080045055 title "Osmosensitive Cl⁻currents and their relevance to regulatory volume decrease in human intestinal T₈₄cells: outwardly<i>vs.</i>inwardly rectifying currents" @default.
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• W2080045055 doi "https://doi.org/10.1111/j.1469-7793.1998.045bi.x" @default.
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