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• W2080092684 abstract "1 Effects of α-adrenoceptor agonists and antagonists with different affinity for α1- and α2-receptors on ouabain-induced arrhythmias in guinea-pigs were studied. 2 Early arrhythmias, ventricular fibrillation and cardiac arrest were induced in anaesthetized guinea-pigs by the slow intravenous infusion of ouabain. 3 Phenylephrine and yohimbine potentiated the cardiotoxicity of ouabain significantly whereas prazosin and clonidine showed significant antiarrhythmic effects and delayed the cardiac arrest. 4 It is concluded that selective α1-receptor stimulation and α2-receptor blockade increases the cardiotoxic effects of ouabain and selective α2-receptor stimulation and α1-receptor blockade inhibits ouabain-induced arrhythmias and cardiac arrest in guinea-pigs." @default.
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• W2080092684 date "1986-10-01" @default.
• W2080092684 modified "2023-09-27" @default.
• W2080092684 title "Effects of α-adrenoceptor agonists and antagonists on ouabain-induced arrhythmias and cardiac arrest in guinea-pig" @default.
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• W2080092684 doi "https://doi.org/10.1111/j.1476-5381.1986.tb10271.x" @default.
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