Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080104057> ?p ?o ?g. }
- W2080104057 endingPage "1208" @default.
- W2080104057 startingPage "1203" @default.
- W2080104057 abstract "The long-term outcomes of endovascular abdominal aortic aneurysm repair (EVAR) remain to be determined, but patients with aneurysm shrinkage after EVAR appear to have a good prognosis. We previously observed that antiplatelet therapy is a risk factor for lack of aneurysm shrinkage, a finding suggesting that coagulation and fibrinolysis play roles in shrinkage. We therefore studied the effect of antifibrinolytic therapy with tranexamic acid (TXA) on aneurysm shrinkage after EVAR.From May 2007 to May 2012, EVAR was performed in 187 patients, 165 of whom had an enhanced computed tomographic evaluation 6 months after their procedure. Six of the 165 patients were excluded from the study because they had a type Ia endoleak or coil embolization to treat a type II endoleak ≤ 6 months after EVAR. Of the remaining 159 patients, 110 underwent EVAR before we started to use TXA in our centers. TXA therapy (1500 mg/d for 6 months) began in January 2011, and 48 patients completed the treatment regimen. Patients not treated with TXA were compared with those given TXA. Analyses to identify risk factors for lack of aneurysm shrinkage were performed.No patient had a thromboembolic event. There were no significant differences between the no-TXA and TXA groups in demographics, aneurysm characteristics, prosthesis implanted, type II endoleak occurrence during EVAR or 1 or 6 months afterward, or aneurysm shrinkage at 1 month. However, at 6 months after EVAR, the TXA group had significantly greater aneurysm shrinkage (P = .035) and a significantly higher percentage of patients with >4 mm in shrinkage (P = .010). Multiple regression analysis showed aneurysm diameter, type II endoleak 6 months after EVAR, and TXA treatment were independently associated with aneurysm shrinkage or lack of shrinkage.Antifibrinolytic therapy with TXA was associated with aneurysm shrinkage after EVAR. Studies to identify the dosage of TXA that is optimally safe and effective in this application, as well as investigations of the best timing and route (parenteral vs oral) for TXA administration, are warranted." @default.
- W2080104057 created "2016-06-24" @default.
- W2080104057 creator A5001035215 @default.
- W2080104057 creator A5039897422 @default.
- W2080104057 creator A5048969687 @default.
- W2080104057 creator A5051839051 @default.
- W2080104057 creator A5054251126 @default.
- W2080104057 creator A5060063986 @default.
- W2080104057 creator A5068548975 @default.
- W2080104057 creator A5080755391 @default.
- W2080104057 date "2014-05-01" @default.
- W2080104057 modified "2023-10-05" @default.
- W2080104057 title "Effect of antifibrinolytic therapy with tranexamic acid on abdominal aortic aneurysm shrinkage after endovascular repair" @default.
- W2080104057 cites W1965280037 @default.
- W2080104057 cites W1965593286 @default.
- W2080104057 cites W1978979864 @default.
- W2080104057 cites W1991078337 @default.
- W2080104057 cites W2013333624 @default.
- W2080104057 cites W2014151892 @default.
- W2080104057 cites W2025718567 @default.
- W2080104057 cites W2028477410 @default.
- W2080104057 cites W2033638207 @default.
- W2080104057 cites W2038142111 @default.
- W2080104057 cites W2039216743 @default.
- W2080104057 cites W2049973937 @default.
- W2080104057 cites W2055255719 @default.
- W2080104057 cites W2068407425 @default.
- W2080104057 cites W2070248706 @default.
- W2080104057 cites W2098276915 @default.
- W2080104057 cites W2107151507 @default.
- W2080104057 cites W2110882504 @default.
- W2080104057 cites W2124146726 @default.
- W2080104057 cites W2126885182 @default.
- W2080104057 cites W2128229225 @default.
- W2080104057 cites W2159180572 @default.
- W2080104057 cites W2160205120 @default.
- W2080104057 cites W2324437595 @default.
- W2080104057 cites W2417436195 @default.
- W2080104057 cites W4238634136 @default.
- W2080104057 cites W4252859197 @default.
- W2080104057 cites W78129447 @default.
- W2080104057 doi "https://doi.org/10.1016/j.jvs.2013.11.006" @default.
- W2080104057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24440679" @default.
- W2080104057 hasPublicationYear "2014" @default.
- W2080104057 type Work @default.
- W2080104057 sameAs 2080104057 @default.
- W2080104057 citedByCount "24" @default.
- W2080104057 countsByYear W20801040572015 @default.
- W2080104057 countsByYear W20801040572016 @default.
- W2080104057 countsByYear W20801040572017 @default.
- W2080104057 countsByYear W20801040572018 @default.
- W2080104057 countsByYear W20801040572020 @default.
- W2080104057 countsByYear W20801040572021 @default.
- W2080104057 countsByYear W20801040572022 @default.
- W2080104057 countsByYear W20801040572023 @default.
- W2080104057 crossrefType "journal-article" @default.
- W2080104057 hasAuthorship W2080104057A5001035215 @default.
- W2080104057 hasAuthorship W2080104057A5039897422 @default.
- W2080104057 hasAuthorship W2080104057A5048969687 @default.
- W2080104057 hasAuthorship W2080104057A5051839051 @default.
- W2080104057 hasAuthorship W2080104057A5054251126 @default.
- W2080104057 hasAuthorship W2080104057A5060063986 @default.
- W2080104057 hasAuthorship W2080104057A5068548975 @default.
- W2080104057 hasAuthorship W2080104057A5080755391 @default.
- W2080104057 hasBestOaLocation W20801040571 @default.
- W2080104057 hasConcept C141071460 @default.
- W2080104057 hasConcept C2776035437 @default.
- W2080104057 hasConcept C2776098176 @default.
- W2080104057 hasConcept C2776543907 @default.
- W2080104057 hasConcept C2777323849 @default.
- W2080104057 hasConcept C2779637338 @default.
- W2080104057 hasConcept C2779993416 @default.
- W2080104057 hasConcept C2780120127 @default.
- W2080104057 hasConcept C2781436528 @default.
- W2080104057 hasConcept C2991743468 @default.
- W2080104057 hasConcept C42219234 @default.
- W2080104057 hasConcept C71924100 @default.
- W2080104057 hasConceptScore W2080104057C141071460 @default.
- W2080104057 hasConceptScore W2080104057C2776035437 @default.
- W2080104057 hasConceptScore W2080104057C2776098176 @default.
- W2080104057 hasConceptScore W2080104057C2776543907 @default.
- W2080104057 hasConceptScore W2080104057C2777323849 @default.
- W2080104057 hasConceptScore W2080104057C2779637338 @default.
- W2080104057 hasConceptScore W2080104057C2779993416 @default.
- W2080104057 hasConceptScore W2080104057C2780120127 @default.
- W2080104057 hasConceptScore W2080104057C2781436528 @default.
- W2080104057 hasConceptScore W2080104057C2991743468 @default.
- W2080104057 hasConceptScore W2080104057C42219234 @default.
- W2080104057 hasConceptScore W2080104057C71924100 @default.
- W2080104057 hasIssue "5" @default.
- W2080104057 hasLocation W20801040571 @default.
- W2080104057 hasLocation W20801040572 @default.
- W2080104057 hasOpenAccess W2080104057 @default.
- W2080104057 hasPrimaryLocation W20801040571 @default.
- W2080104057 hasRelatedWork W1982778236 @default.
- W2080104057 hasRelatedWork W2036903459 @default.
- W2080104057 hasRelatedWork W2088352857 @default.
- W2080104057 hasRelatedWork W2090543750 @default.