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- W2080126276 abstract "Several blood biomarkers have been identified which are helpful in supporting atrial fibrillation (AF) diagnosis, prognosis, and outcomes. Because of its involvement in cardiac fibrosis, inflammation, and remodeling processes, galectin-3 is one of the emerging biomarkers in cardiac diseases. 1 Yu L. Ruifrok W.P. Meissner M. Bos E.M. van Goor H. Sanjabi B. van der Harst P. Pitt B. Goldstein I.J. Koerts J.A. van Veldhuisen D.J. Bank R.A. van Gilst W.H. Sillje H.H. de Boer R.A. Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis. Circ Heart Fail. 2013; 6: 107-117 Crossref PubMed Scopus (309) Google Scholar Together with NT-proBNP, galectin-3 demonstrated better prognostic value for mortality in general population and in patients with heart failure, 2 van Kimmenade R.R. Januzzi Jr., J.L. Ellinor P.T. Sharma U.C. Bakker J.A. Low A.F. Martinez A. Crijns H.J. MacRae C.A. Menheere P.P. Pinto Y.M. Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol. 2006; 48: 1217-1224 Abstract Full Text Full Text PDF PubMed Scopus (451) Google Scholar although it has been already demonstrated that galectin-3 has a lower specificity and sensitivity to identify patients with acute heart failure than NT-proBNP. 3 van Kimmenade R. van Dielen F. Bakker J. Nijhuis J. Crijns H. Buurman W. van Dieijen-Visser M. Greve J.W. Pinto Y. Is brain natriuretic peptide production decreased in obese subjects?. J Am Coll Cardiol. 2006; 47: 886-887 Abstract Full Text Full Text PDF PubMed Scopus (41) Google Scholar Effects of Persistent Atrial Fibrillation on Serum Galectin-3 LevelsAmerican Journal of CardiologyVol. 115Issue 5PreviewGalectin-3 is known to play an important role in a number of fibrotic conditions, including cardiac fibrosis. Many studies have focused on the association between galectin-3 levels and cardiac fibrosis in heart failure. However, the role of galectin-3 in the pathogenesis of atrial fibrillation (AF) has not been evaluated thoroughly yet. The aim of this study was to determine whether serum galectin-3 levels were elevated in patients with AF and preserved left ventricular function. Seventy-six patients with paroxysmal or persistent AF and preserved left ventricular systolic function and 75 age- and gender-matched control subjects were enrolled in this observational study. Full-Text PDF ReplyAmerican Journal of CardiologyVol. 116Issue 1PreviewWe read the letter by Kornej et al and thank them for their comments regarding our studies1,2 evaluating the relation between serum galectin-3 levels and atrial fibrillation. Full-Text PDF" @default.
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- W2080126276 title "Galectin-3 in Atrial Fibrillation: A Novel Marker of Atrial Remodeling or Just Bystander?" @default.
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- W2080126276 doi "https://doi.org/10.1016/j.amjcard.2015.03.055" @default.
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