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• W2080132103 abstract "Summary Purpose The study of the interactions leading to network‐ or region‐specific propagation of seizures is crucial to understand ictogenesis. We have recently found that systemic (arterial) application of the potassium channel blocker, 4‐aminopyridine (4 AP ), induces different and independent seizure activities in olfactory and in limbic structures. Here, we have characterized the network and cellular features that support 4 AP ‐induced seizure‐like events in the olfactory cortex. Methods Simultaneous extracellular recordings were performed from the piriform cortex, the entorhinal cortex, the olfactory tubercle, and the amygdala of the in vitro isolated guinea pig brain preparation. Intracellular, sharp electrode recordings were obtained from neurons of different layers of the region of ictal onset, the piriform cortex. Seizure‐like discharges were induced by both arterial perfusion and local intracortical injections of 4 AP . Key Findings Arterial application of 4 AP induces independent seizure activities in limbic and olfactory cortices. Both local applications of 4 AP and cortico‐cortical disconnections demonstrated that region‐specific seizure‐like events initiated in the primary olfactory cortex and propagate to anatomically related areas. Seizures induced by arterial administration of 4‐ AP are preceded by runs of fast activity at circa 30–40 Hz and are independently generated in the hemispheres. Simultaneous extracellular and intracellular recordings in the piriform cortex revealed that the onset of seizure correlates with (1) a gradual amplitude increase of fast activity runs, (2) a large intracellular depolarization with action potential firing of superficial layer neurons, and (3) no firing in a subpopulation of deep layers neurons. During the ictal event, neuronal firing was abolished for 10–30 s in all neurons and gradually restored and synchronized before seizure termination. Significance Our data show that olfactory neuronal networks sustain the generation of seizure‐like activities that are independent from those observed in adjacent and connected limbic cortex regions. The data support the concept that functionally and anatomically hard‐wired networks generate region‐specific seizure patterns that could be substrates for system epilepsy." @default.
• W2080132103 created "2016-06-24" @default.
• W2080132103 creator A5007468350 @default.
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• W2080132103 creator A5043413367 @default.
• W2080132103 date "2013-03-18" @default.
• W2080132103 modified "2023-10-17" @default.
• W2080132103 title "Seizure-like discharges induced by 4-aminopyridine in the olfactory system of the in vitro isolated guinea pig brain" @default.
• W2080132103 cites W1501375812 @default.
• W2080132103 cites W1555946311 @default.
• W2080132103 cites W1592280048 @default.
• W2080132103 cites W1695583884 @default.
• W2080132103 cites W1750953121 @default.
• W2080132103 cites W1960266861 @default.
• W2080132103 cites W1963710870 @default.
• W2080132103 cites W1965934155 @default.
• W2080132103 cites W1973400846 @default.
• W2080132103 cites W1974187631 @default.
• W2080132103 cites W1975305872 @default.
• W2080132103 cites W1985837121 @default.
• W2080132103 cites W1988334578 @default.
• W2080132103 cites W1989749966 @default.
• W2080132103 cites W1990458657 @default.
• W2080132103 cites W1993340311 @default.
• W2080132103 cites W1994519057 @default.
• W2080132103 cites W1996186169 @default.
• W2080132103 cites W1997566072 @default.
• W2080132103 cites W2002010598 @default.
• W2080132103 cites W2002608596 @default.
• W2080132103 cites W2004848665 @default.
• W2080132103 cites W2007773833 @default.
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• W2080132103 cites W2036710446 @default.
• W2080132103 cites W2043017375 @default.
• W2080132103 cites W2046361252 @default.
• W2080132103 cites W2052070189 @default.
• W2080132103 cites W2058581576 @default.
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• W2080132103 cites W2095421040 @default.
• W2080132103 cites W2098342239 @default.
• W2080132103 cites W2099478180 @default.
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• W2080132103 cites W2278482967 @default.
• W2080132103 cites W2321918100 @default.
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• W2080132103 doi "https://doi.org/10.1111/epi.12133" @default.
• W2080132103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4891192" @default.
• W2080132103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23505998" @default.
• W2080132103 hasPublicationYear "2013" @default.
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