FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080132904> ?p ?o ?g. }

• W2080132904 abstract "The avian sarcoma viruses FSV, PRCII, PRCIIp, and PRCIV share a related class of hybrid onc genes (delta gag-fps) defined by a specific nucleotide sequence fps and by delta gag-fps proteins of different sizes. Among these viruses, PRCII appears to have a lower tumorigenic potential than the others. Here we have compared fibroblast-transforming function and onc gene structure of these viruses. The fibroblast transforming ability of PRCII was lower than those of FSV, PRCIIp, and PRCIV. By gel electrophoresis the genomic RNA of PRCII measured 3.5 kb and those of FSV, PRCIIp, and PRCIV 4.5 kb; the delta gag-fps protein of PRCII measured 105 kilodaltons (kd), that of FSV 140 kd, and those of PRCIIp and PRCIV about 150 kd. By fingerprinting viral RNAs hybridized with molecularly cloned viral DNA the delta gag regions of PRCII and PRCIIp were defined to be 1.45 kb and that of FSV to be 1.3 kb. Fingerprint analysis of viral RNA-proto fps DNA hybrids showed the fps regions (approximately 2.8 kb) of FSV and PRCIIp to be isogenic. Compared to FSV and PRCIIp, the fps sequence of PRCII lacked a 1-kb region which maps between 0.3 and 1.3 kb from the 5' end of fps in FSV and PRCIIp. Based on oligonucleotide analysis, the shared fps complements of PRCII and PRCIIp were indistinguishable while that of FSV differed from those of the PRC viruses in scattered point mutations amounting to 1-2% of the RNA. Since all other regions of PRCII are isogenic with those of the highly tumorigenic variants PRCIIp, PRCIV, and FSV, it is concluded that the low fibroblast-transforming and oncogenic potential of PRCII reflects the internal fps deletion. Since the fps deletion reduces but does not eliminate transforming function, we suggest that the complete onc genes of viruses in the FSV subgroup include either several functional, or a regulatory and a functional fibroblast transforming domain. It has been reported that the 3' domains of the onc genes of viruses in the Fujinami subgroup and the onc genes of certain feline sarcoma viruses are distantly related. Since full transforming potential of the avian viruses depends on the 5' fps region not shared with the feline sarcoma viruses, we suggest that despite their structural homology, the avian and feline onc genes must have functionally different domains." @default.
• W2080132904 created "2016-06-24" @default.
• W2080132904 creator A5010111166 @default.
• W2080132904 creator A5061314864 @default.
• W2080132904 creator A5064087933 @default.
• W2080132904 date "1983-11-01" @default.
• W2080132904 modified "2023-09-26" @default.
• W2080132904 title "The low tumorigenic potential of PRCII, among viruses of the Fujinami sarcoma virus subgroup, corresponds to an internal (fps) deletion of the transforming gene" @default.
• W2080132904 cites W1487674467 @default.
• W2080132904 cites W1547991831 @default.
• W2080132904 cites W1552361725 @default.
• W2080132904 cites W1555721065 @default.
• W2080132904 cites W1565385222 @default.
• W2080132904 cites W1566693005 @default.
• W2080132904 cites W1689612166 @default.
• W2080132904 cites W1791604348 @default.
• W2080132904 cites W1914348560 @default.
• W2080132904 cites W1954522192 @default.
• W2080132904 cites W1966583165 @default.
• W2080132904 cites W1974768251 @default.
• W2080132904 cites W1999014384 @default.
• W2080132904 cites W2017952940 @default.
• W2080132904 cites W2032309880 @default.
• W2080132904 cites W2037198776 @default.
• W2080132904 cites W2040026704 @default.
• W2080132904 cites W2041479068 @default.
• W2080132904 cites W2046560188 @default.
• W2080132904 cites W2053519157 @default.
• W2080132904 cites W2057301899 @default.
• W2080132904 cites W2067019332 @default.
• W2080132904 cites W2071366840 @default.
• W2080132904 cites W2081930669 @default.
• W2080132904 cites W2086280546 @default.
• W2080132904 cites W2086684937 @default.
• W2080132904 cites W2100837269 @default.
• W2080132904 cites W2108415249 @default.
• W2080132904 cites W2119430582 @default.
• W2080132904 cites W2135380694 @default.
• W2080132904 cites W2148043496 @default.
• W2080132904 cites W2165794386 @default.
• W2080132904 cites W2321925297 @default.
• W2080132904 doi "https://doi.org/10.1016/0042-6822(83)90541-x" @default.
• W2080132904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6316648" @default.
• W2080132904 hasPublicationYear "1983" @default.
• W2080132904 type Work @default.
• W2080132904 sameAs 2080132904 @default.
• W2080132904 citedByCount "17" @default.
• W2080132904 crossrefType "journal-article" @default.
• W2080132904 hasAuthorship W2080132904A5010111166 @default.
• W2080132904 hasAuthorship W2080132904A5061314864 @default.
• W2080132904 hasAuthorship W2080132904A5064087933 @default.
• W2080132904 hasConcept C104317684 @default.
• W2080132904 hasConcept C129312508 @default.
• W2080132904 hasConcept C153911025 @default.
• W2080132904 hasConcept C159047783 @default.
• W2080132904 hasConcept C54355233 @default.
• W2080132904 hasConcept C552990157 @default.
• W2080132904 hasConcept C67705224 @default.
• W2080132904 hasConcept C86803240 @default.
• W2080132904 hasConceptScore W2080132904C104317684 @default.
• W2080132904 hasConceptScore W2080132904C129312508 @default.
• W2080132904 hasConceptScore W2080132904C153911025 @default.
• W2080132904 hasConceptScore W2080132904C159047783 @default.
• W2080132904 hasConceptScore W2080132904C54355233 @default.
• W2080132904 hasConceptScore W2080132904C552990157 @default.
• W2080132904 hasConceptScore W2080132904C67705224 @default.
• W2080132904 hasConceptScore W2080132904C86803240 @default.
• W2080132904 hasLocation W20801329041 @default.
• W2080132904 hasLocation W20801329042 @default.
• W2080132904 hasOpenAccess W2080132904 @default.
• W2080132904 hasPrimaryLocation W20801329041 @default.
• W2080132904 hasRelatedWork W1996555041 @default.
• W2080132904 hasRelatedWork W2002473487 @default.
• W2080132904 hasRelatedWork W2051801995 @default.
• W2080132904 hasRelatedWork W2055778129 @default.
• W2080132904 hasRelatedWork W2060958215 @default.
• W2080132904 hasRelatedWork W2078865641 @default.
• W2080132904 hasRelatedWork W2119463312 @default.
• W2080132904 hasRelatedWork W2171277769 @default.
• W2080132904 hasRelatedWork W2346693789 @default.
• W2080132904 hasRelatedWork W4239604825 @default.
• W2080132904 isParatext "false" @default.
• W2080132904 isRetracted "false" @default.
• W2080132904 magId "2080132904" @default.
• W2080132904 workType "article" @default.