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• W2080136005 endingPage "e26736" @default.
• W2080136005 startingPage "e26736" @default.
• W2080136005 abstract "Leptospira interrogans is a bacterium that is capable of infecting animals and humans, and its infection causes leptospirosis with a range of symptoms from flu-like to severe illness and death. Despite being a bacteria, Leptospira interrogans contains a plastidic class ferredoxin-NADP(H) reductase (FNR) with high catalytic efficiency, at difference from the bacterial class FNRs. These flavoenzymes catalyze the electron transfer between NADP(H) and ferredoxins or flavodoxins. The inclusion of a plastidic FNR in Leptospira metabolism and in its parasitic life cycle is not currently understood. Bioinformatic analyses of the available genomic and proteins sequences showed that the presence of this enzyme in nonphotosynthetic bacteria is restricted to the Leptospira genus and that a [4Fe-4S] ferredoxin (LB107) encoded by the Leptospira genome may be the natural substrate of the enzyme. Leptospira FNR (LepFNR) displayed high diaphorase activity using artificial acceptors and functioned as a ferric reductase. LepFNR displayed cytochrome c reductase activity with the Leptospira LB107 ferredoxin with an optimum at pH 6.5. Structural stability analysis demonstrates that LepFNR is one of the most stable FNRs analyzed to date. The persistence of a native folded LepFNR structure was detected in up to 6 M urea, a condition in which the enzyme retains 38% activity. In silico analysis indicates that the high LepFNR stability might be due to robust interactions between the FAD and the NADP+ domains of the protein. The limited bacterial distribution of plastidic class FNRs and the biochemical and structural properties of LepFNR emphasize the uniqueness of this enzyme in the Leptospira metabolism. Our studies show that in L. interrogans a plastidic-type FNR exchanges electrons with a bacterial-type ferredoxin, process which has not been previously observed in nature." @default.
• W2080136005 created "2016-06-24" @default.
• W2080136005 creator A5012915348 @default.
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• W2080136005 creator A5080514823 @default.
• W2080136005 creator A5081628552 @default.
• W2080136005 date "2011-10-24" @default.
• W2080136005 modified "2023-09-25" @default.
• W2080136005 title "A Highly Stable Plastidic-Type Ferredoxin-NADP(H) Reductase in the Pathogenic Bacterium Leptospira interrogans" @default.
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• W2080136005 doi "https://doi.org/10.1371/journal.pone.0026736" @default.
• W2080136005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3200346" @default.
• W2080136005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22039544" @default.
• W2080136005 hasPublicationYear "2011" @default.
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