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• W2080147178 abstract "Although aggressive public health measures have greatly reduced the number of brucellosis cases in the United States, there is a resurgence of interest in this worldwide zoonosis because of its potential as a bioweapon and its 8-fold higher incidence in California, Texas, and the other borderlands between the United States and Mexico compared with the national rate. Accordingly, we reviewed the clinical records of 28 patients diagnosed at a university hospital in San Diego, CA, between 1979 and 2002 to look for new epidemiologic trends and to test the hypothesis that there are species-specific differences in clinical presentations. In contrast to the latest California-wide study completed in 1992, Brucella abortus infections were more common (73%) than Brucella melitensis after 1992, and women were more commonly infected (77% compared with 39%) than men. Major risk factors remained Hispanic ethnicity, travel to Mexico, and ingestion of nonpasteurized dairy products. Analysis of diagnostic procedures suggested that the traditional practice of prolonged incubation of blood cultures increased their sensitivity for Brucella, even in automated radiometric systems. Direct comparison of the clinical manifestations of infections with B. abortus and B. melitensis strongly supported differences in acute presentations. B. melitensis presented more acutely as fevers of unknown origin with statistically significant higher rates of abdominal tenderness, hepatomegaly, splenomegaly, thrombocytopenia, pancytopenia, and hepatic dysfunction. These results suggest that the epidemiology of brucellosis in California may be evolving, and they show, to our knowledge for the first time in a single series, that species-specific differences in presentations may account for some of the protean manifestations of brucellosis. Familiarity with manifestations of brucellosis and the optimal laboratory techniques for its diagnosis could help physicians protect the public against this reemerging, under-recognized zoonosis. Abbreviations: FUO = fever of unknown origin, SAT = slide agglutination test." @default.
• W2080147178 created "2016-06-24" @default.
• W2080147178 creator A5053137835 @default.
• W2080147178 creator A5072654723 @default.
• W2080147178 creator A5089681143 @default.
• W2080147178 date "2005-05-01" @default.
• W2080147178 modified "2023-09-30" @default.
• W2080147178 title "Brucellosis in San Diego" @default.
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• W2080147178 doi "https://doi.org/10.1097/01.md.0000165659.20988.25" @default.
• W2080147178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15879907" @default.
• W2080147178 hasPublicationYear "2005" @default.
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