FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080147271> ?p ?o ?g. }

• W2080147271 endingPage "82" @default.
• W2080147271 startingPage "74" @default.
• W2080147271 abstract "Cysteamine is a degradation product of the amino acid cysteine and a reduced form of cystamine. Cysteamine exhibits strong antioxidant activity and has been implicated in the treatment of neurodegenerative disorders such as Huntington's disease. In the present study, we investigated whether cysteamine confers protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced toxicity in the dopaminergic neurons in a mouse model for Parkinson's disease (PD). The loss of dopaminergic (DA) neurons and reduction in striatal DA concentrations induced by MPTP was ameliorated to a significant extent by pretreatment with low (20 mg/kg/day), but not high (75 mg/kg/day), dose of cysteamine 4 days prior to and subsequently along with the MPTP treatment. Consistently, the increased production of pro-oxidants, such as reactive oxygen species (ROS) and malondialdehyde (MDA), was significantly suppressed by low dose of cysteamine. Conversely, the reduction in GSH level caused by MPTP exposure was significantly attenuated by pretreatment of cysteamine. In addition, the inhibited secretion of the brain-derived neurotrophic factor (BDNF) by neurons derived from substantia nigra pars compact (SNpc) of MPTP-treated mice was significantly restored by cysteamine administration. Our results demonstrate that cysteamine at low dose confers potent neuroprotection against MPTP-induced toxicity of dopaminergic neurons, and may become a potential therapeutic strategy for PD." @default.
• W2080147271 created "2016-06-24" @default.
• W2080147271 creator A5009143289 @default.
• W2080147271 creator A5040284436 @default.
• W2080147271 creator A5042646731 @default.
• W2080147271 creator A5050112775 @default.
• W2080147271 creator A5051874918 @default.
• W2080147271 creator A5079487079 @default.
• W2080147271 date "2010-06-01" @default.
• W2080147271 modified "2023-10-18" @default.
• W2080147271 title "Effects of cysteamine on MPTP-induced dopaminergic neurodegeneration in mice" @default.
• W2080147271 cites W1493424786 @default.
• W2080147271 cites W1775749144 @default.
• W2080147271 cites W1973601740 @default.
• W2080147271 cites W1974792405 @default.
• W2080147271 cites W1976679890 @default.
• W2080147271 cites W1979525257 @default.
• W2080147271 cites W1980854786 @default.
• W2080147271 cites W1992962942 @default.
• W2080147271 cites W1995376416 @default.
• W2080147271 cites W2011323367 @default.
• W2080147271 cites W2013013539 @default.
• W2080147271 cites W2014817776 @default.
• W2080147271 cites W2022659240 @default.
• W2080147271 cites W2041047805 @default.
• W2080147271 cites W2051229117 @default.
• W2080147271 cites W2060750433 @default.
• W2080147271 cites W2062795528 @default.
• W2080147271 cites W2072143544 @default.
• W2080147271 cites W2073847915 @default.
• W2080147271 cites W2073916112 @default.
• W2080147271 cites W2074782316 @default.
• W2080147271 cites W2080267632 @default.
• W2080147271 cites W2080562682 @default.
• W2080147271 cites W2092050115 @default.
• W2080147271 cites W2107007950 @default.
• W2080147271 cites W2118844577 @default.
• W2080147271 cites W2122618654 @default.
• W2080147271 cites W2127820852 @default.
• W2080147271 cites W2143935514 @default.
• W2080147271 cites W2146431823 @default.
• W2080147271 cites W2161804912 @default.
• W2080147271 cites W2169287384 @default.
• W2080147271 cites W74014991 @default.
• W2080147271 doi "https://doi.org/10.1016/j.brainres.2010.03.079" @default.
• W2080147271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20380823" @default.
• W2080147271 hasPublicationYear "2010" @default.
• W2080147271 type Work @default.
• W2080147271 sameAs 2080147271 @default.
• W2080147271 citedByCount "40" @default.
• W2080147271 countsByYear W20801472712012 @default.
• W2080147271 countsByYear W20801472712013 @default.
• W2080147271 countsByYear W20801472712014 @default.
• W2080147271 countsByYear W20801472712015 @default.
• W2080147271 countsByYear W20801472712016 @default.
• W2080147271 countsByYear W20801472712017 @default.
• W2080147271 countsByYear W20801472712018 @default.
• W2080147271 countsByYear W20801472712019 @default.
• W2080147271 countsByYear W20801472712020 @default.
• W2080147271 countsByYear W20801472712021 @default.
• W2080147271 countsByYear W20801472712022 @default.
• W2080147271 countsByYear W20801472712023 @default.
• W2080147271 crossrefType "journal-article" @default.
• W2080147271 hasAuthorship W2080147271A5009143289 @default.
• W2080147271 hasAuthorship W2080147271A5040284436 @default.
• W2080147271 hasAuthorship W2080147271A5042646731 @default.
• W2080147271 hasAuthorship W2080147271A5050112775 @default.
• W2080147271 hasAuthorship W2080147271A5051874918 @default.
• W2080147271 hasAuthorship W2080147271A5079487079 @default.
• W2080147271 hasConcept C126322002 @default.
• W2080147271 hasConcept C134018914 @default.
• W2080147271 hasConcept C137183658 @default.
• W2080147271 hasConcept C178790620 @default.
• W2080147271 hasConcept C185592680 @default.
• W2080147271 hasConcept C25498285 @default.
• W2080147271 hasConcept C2776609658 @default.
• W2080147271 hasConcept C2776925932 @default.
• W2080147271 hasConcept C2778674702 @default.
• W2080147271 hasConcept C2779134260 @default.
• W2080147271 hasConcept C2780938664 @default.
• W2080147271 hasConcept C2781159505 @default.
• W2080147271 hasConcept C29730261 @default.
• W2080147271 hasConcept C513476851 @default.
• W2080147271 hasConcept C55493867 @default.
• W2080147271 hasConcept C71924100 @default.
• W2080147271 hasConcept C98274493 @default.
• W2080147271 hasConceptScore W2080147271C126322002 @default.
• W2080147271 hasConceptScore W2080147271C134018914 @default.
• W2080147271 hasConceptScore W2080147271C137183658 @default.
• W2080147271 hasConceptScore W2080147271C178790620 @default.
• W2080147271 hasConceptScore W2080147271C185592680 @default.
• W2080147271 hasConceptScore W2080147271C25498285 @default.
• W2080147271 hasConceptScore W2080147271C2776609658 @default.
• W2080147271 hasConceptScore W2080147271C2776925932 @default.
• W2080147271 hasConceptScore W2080147271C2778674702 @default.
• W2080147271 hasConceptScore W2080147271C2779134260 @default.
• W2080147271 hasConceptScore W2080147271C2780938664 @default.
• W2080147271 hasConceptScore W2080147271C2781159505 @default.

• next