Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080166395> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2080166395 endingPage "371" @default.
- W2080166395 startingPage "364" @default.
- W2080166395 abstract "Cicletanine, a furopyridine-derivative drug, was shown to enhance the production of endogenous prostacyclin. The potent vasodilating properties of prostacyclin are used to treat severe primary pulmonary hypertension. Prostacyclin has a short half-life and can be administered only as an i.v. infusion. The aim of this study was to evaluate the effects of cicletanine on pulmonary artery hypertension (PAH) resulting from chronic obstructive lung disease (COLD). In a double-blind controlled study, we evaluated the effects of short- and long-term administration of cicletanine (50 mg daily, orally) on hemodynamics and blood gases of patients with PAH resulting from COLD. The initial dose of 50 mg of cicletanine had no effect. A significant decrease in the mean pulmonary artery pressure (15%) and in total pulmonary resistance (20%) was observed after 3 or 12 months of treatment in the cicletanine group (11 patients), when compared with placebo (12 patients). PaO2 decreased slightly in the cicletanine group, but the difference from the control group was not significant. These results suggest that long-term treatment with cicletanine can induce effective pulmonary vasodilation in patients with PAH caused by COLD and that this is probably responsible for a small venous admixture." @default.
- W2080166395 created "2016-06-24" @default.
- W2080166395 creator A5014460906 @default.
- W2080166395 creator A5045816459 @default.
- W2080166395 creator A5061576564 @default.
- W2080166395 creator A5069234010 @default.
- W2080166395 creator A5081088034 @default.
- W2080166395 date "1998-03-01" @default.
- W2080166395 modified "2023-10-17" @default.
- W2080166395 title "Long-Term Effects of Cicletanine on Secondary Pulmonary Hypertension" @default.
- W2080166395 cites W1979969712 @default.
- W2080166395 cites W1990060127 @default.
- W2080166395 cites W1991370314 @default.
- W2080166395 cites W1992900905 @default.
- W2080166395 cites W1995272882 @default.
- W2080166395 cites W1999766108 @default.
- W2080166395 cites W2000554450 @default.
- W2080166395 cites W2025166158 @default.
- W2080166395 cites W2045748286 @default.
- W2080166395 cites W2052863233 @default.
- W2080166395 cites W2061098585 @default.
- W2080166395 cites W2062256657 @default.
- W2080166395 cites W2081408852 @default.
- W2080166395 cites W2084853767 @default.
- W2080166395 cites W2089921962 @default.
- W2080166395 cites W2142044870 @default.
- W2080166395 cites W2166725874 @default.
- W2080166395 cites W4205209053 @default.
- W2080166395 doi "https://doi.org/10.1097/00005344-199803000-00006" @default.
- W2080166395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9514180" @default.
- W2080166395 hasPublicationYear "1998" @default.
- W2080166395 type Work @default.
- W2080166395 sameAs 2080166395 @default.
- W2080166395 citedByCount "34" @default.
- W2080166395 countsByYear W20801663952012 @default.
- W2080166395 countsByYear W20801663952013 @default.
- W2080166395 countsByYear W20801663952014 @default.
- W2080166395 countsByYear W20801663952015 @default.
- W2080166395 countsByYear W20801663952016 @default.
- W2080166395 countsByYear W20801663952018 @default.
- W2080166395 countsByYear W20801663952019 @default.
- W2080166395 countsByYear W20801663952021 @default.
- W2080166395 countsByYear W20801663952022 @default.
- W2080166395 crossrefType "journal-article" @default.
- W2080166395 hasAuthorship W2080166395A5014460906 @default.
- W2080166395 hasAuthorship W2080166395A5045816459 @default.
- W2080166395 hasAuthorship W2080166395A5061576564 @default.
- W2080166395 hasAuthorship W2080166395A5069234010 @default.
- W2080166395 hasAuthorship W2080166395A5081088034 @default.
- W2080166395 hasBestOaLocation W20801663951 @default.
- W2080166395 hasConcept C120770815 @default.
- W2080166395 hasConcept C126322002 @default.
- W2080166395 hasConcept C142724271 @default.
- W2080166395 hasConcept C164705383 @default.
- W2080166395 hasConcept C178853913 @default.
- W2080166395 hasConcept C204787440 @default.
- W2080166395 hasConcept C27081682 @default.
- W2080166395 hasConcept C2780930700 @default.
- W2080166395 hasConcept C2780940725 @default.
- W2080166395 hasConcept C2781128415 @default.
- W2080166395 hasConcept C58245268 @default.
- W2080166395 hasConcept C71924100 @default.
- W2080166395 hasConcept C98274493 @default.
- W2080166395 hasConceptScore W2080166395C120770815 @default.
- W2080166395 hasConceptScore W2080166395C126322002 @default.
- W2080166395 hasConceptScore W2080166395C142724271 @default.
- W2080166395 hasConceptScore W2080166395C164705383 @default.
- W2080166395 hasConceptScore W2080166395C178853913 @default.
- W2080166395 hasConceptScore W2080166395C204787440 @default.
- W2080166395 hasConceptScore W2080166395C27081682 @default.
- W2080166395 hasConceptScore W2080166395C2780930700 @default.
- W2080166395 hasConceptScore W2080166395C2780940725 @default.
- W2080166395 hasConceptScore W2080166395C2781128415 @default.
- W2080166395 hasConceptScore W2080166395C58245268 @default.
- W2080166395 hasConceptScore W2080166395C71924100 @default.
- W2080166395 hasConceptScore W2080166395C98274493 @default.
- W2080166395 hasIssue "3" @default.
- W2080166395 hasLocation W20801663951 @default.
- W2080166395 hasLocation W20801663952 @default.
- W2080166395 hasLocation W20801663953 @default.
- W2080166395 hasOpenAccess W2080166395 @default.
- W2080166395 hasPrimaryLocation W20801663951 @default.
- W2080166395 hasRelatedWork W1975961217 @default.
- W2080166395 hasRelatedWork W1978898645 @default.
- W2080166395 hasRelatedWork W2009332475 @default.
- W2080166395 hasRelatedWork W2028795935 @default.
- W2080166395 hasRelatedWork W2077514360 @default.
- W2080166395 hasRelatedWork W2116192400 @default.
- W2080166395 hasRelatedWork W2151704317 @default.
- W2080166395 hasRelatedWork W2418362533 @default.
- W2080166395 hasRelatedWork W3150445391 @default.
- W2080166395 hasRelatedWork W2254863832 @default.
- W2080166395 hasVolume "31" @default.
- W2080166395 isParatext "false" @default.
- W2080166395 isRetracted "false" @default.
- W2080166395 magId "2080166395" @default.
- W2080166395 workType "article" @default.