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• W2080176196 abstract "The natural amino acids tyrosine (Tyr) and phenylalanine (Phe) were labeled with carbon-11 via a modified Bucherer-Strecker synthesis. A rapid reaction of the sodium bisulfite adduct of the aldehyde precursor with ammonia provided the precursor for radiosynthesis. [(11)C]Cyanide displacement followed by base hydrolysis afforded the corresponding (11)C-labeled amino acids. The purification and chiral separation were simply achieved by using a combination of solid-phase extraction and chiral HPLC to afford individual enantiomers of each amino acid. The decay corrected radiochemical yields for each of the enantiomers were 12-16% with respect to the [(11)C]cyanide after 40-45 min of radiosynthesis. Radiochemical purity of the products was >97% (typically >99%), enantiomeric excess was >98% with the specific radioactivity 2-3 Ci/micromol at the end of bombardment. Because of its simplicity and wide applicability, the described procedure could be the method of choice to produce [(11)C]amino acids for PET studies." @default.
• W2080176196 created "2016-06-24" @default.
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• W2080176196 date "2003-01-01" @default.
• W2080176196 modified "2023-10-03" @default.
• W2080176196 title "Synthesis of no-carrier-added C-11 labeled D- and L-enantiomers of phenylalanine and tyrosine for comparative PET Studies" @default.
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• W2080176196 doi "https://doi.org/10.1016/s0969-8051(02)00349-9" @default.
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