Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080180863> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2080180863 endingPage "96" @default.
- W2080180863 startingPage "89" @default.
- W2080180863 abstract "The PAUSE software has been developed as a new tool to study translational control over protein targeting. This makes it possible to correlate the position of clusters of rare codons in a gene, predicted to cause a translational pause, with the position of hydrophobic stretches in the encoded protein, predicted to span a membrane or to act as a cleavable signal for targeting to the secretory pathway. Furthermore, this software gathers these correlations over whole sets of genes. The PAUSE software is described here, and its use is illustrated on a set of membrane proteins from the fungus Emericella nidulans. Preferential distances of about 45 codons and of about 70 codons between putative transmembrane domains and predicted translational pauses were observed. Given that ≈30 residues are required to span the large ribosomal subunit, the predicted pauses would therefore occur when the hydrophobic domain starts protruding from the ribosome (‘+45 pause’), or fully protrudes as a hairpin (‘+70 pause’). Thus, these specific pauses might reflect a translational control over membrane protein targeting or early recognition (‘+45 pause’), and over insertion or folding (‘+70 pause’)." @default.
- W2080180863 created "2016-06-24" @default.
- W2080180863 creator A5052082741 @default.
- W2080180863 creator A5067773016 @default.
- W2080180863 date "2000-02-01" @default.
- W2080180863 modified "2023-09-25" @default.
- W2080180863 title "The PAUSE software for analysis of translational control over protein targeting: application to E. nidulans membrane proteins" @default.
- W2080180863 cites W1504552716 @default.
- W2080180863 cites W1974557906 @default.
- W2080180863 cites W2018590530 @default.
- W2080180863 cites W2022410950 @default.
- W2080180863 cites W2035945428 @default.
- W2080180863 cites W2047392386 @default.
- W2080180863 cites W2051293392 @default.
- W2080180863 cites W2057097492 @default.
- W2080180863 cites W2063384315 @default.
- W2080180863 cites W2072220895 @default.
- W2080180863 cites W2080731394 @default.
- W2080180863 cites W2081020710 @default.
- W2080180863 cites W2088264371 @default.
- W2080180863 cites W2120684043 @default.
- W2080180863 cites W2138721124 @default.
- W2080180863 cites W2138879032 @default.
- W2080180863 cites W2144112248 @default.
- W2080180863 doi "https://doi.org/10.1016/s0378-1119(00)00002-0" @default.
- W2080180863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10689191" @default.
- W2080180863 hasPublicationYear "2000" @default.
- W2080180863 type Work @default.
- W2080180863 sameAs 2080180863 @default.
- W2080180863 citedByCount "6" @default.
- W2080180863 countsByYear W20801808632012 @default.
- W2080180863 countsByYear W20801808632014 @default.
- W2080180863 countsByYear W20801808632018 @default.
- W2080180863 countsByYear W20801808632019 @default.
- W2080180863 crossrefType "journal-article" @default.
- W2080180863 hasAuthorship W2080180863A5052082741 @default.
- W2080180863 hasAuthorship W2080180863A5067773016 @default.
- W2080180863 hasConcept C104292427 @default.
- W2080180863 hasConcept C104317684 @default.
- W2080180863 hasConcept C105580179 @default.
- W2080180863 hasConcept C118892022 @default.
- W2080180863 hasConcept C144647389 @default.
- W2080180863 hasConcept C149364088 @default.
- W2080180863 hasConcept C170493617 @default.
- W2080180863 hasConcept C24530287 @default.
- W2080180863 hasConcept C41625074 @default.
- W2080180863 hasConcept C54355233 @default.
- W2080180863 hasConcept C67705224 @default.
- W2080180863 hasConcept C70721500 @default.
- W2080180863 hasConcept C86803240 @default.
- W2080180863 hasConcept C88478588 @default.
- W2080180863 hasConcept C95444343 @default.
- W2080180863 hasConceptScore W2080180863C104292427 @default.
- W2080180863 hasConceptScore W2080180863C104317684 @default.
- W2080180863 hasConceptScore W2080180863C105580179 @default.
- W2080180863 hasConceptScore W2080180863C118892022 @default.
- W2080180863 hasConceptScore W2080180863C144647389 @default.
- W2080180863 hasConceptScore W2080180863C149364088 @default.
- W2080180863 hasConceptScore W2080180863C170493617 @default.
- W2080180863 hasConceptScore W2080180863C24530287 @default.
- W2080180863 hasConceptScore W2080180863C41625074 @default.
- W2080180863 hasConceptScore W2080180863C54355233 @default.
- W2080180863 hasConceptScore W2080180863C67705224 @default.
- W2080180863 hasConceptScore W2080180863C70721500 @default.
- W2080180863 hasConceptScore W2080180863C86803240 @default.
- W2080180863 hasConceptScore W2080180863C88478588 @default.
- W2080180863 hasConceptScore W2080180863C95444343 @default.
- W2080180863 hasIssue "1-2" @default.
- W2080180863 hasLocation W20801808631 @default.
- W2080180863 hasLocation W20801808632 @default.
- W2080180863 hasOpenAccess W2080180863 @default.
- W2080180863 hasPrimaryLocation W20801808631 @default.
- W2080180863 hasRelatedWork W169579618 @default.
- W2080180863 hasRelatedWork W1980573183 @default.
- W2080180863 hasRelatedWork W2025692083 @default.
- W2080180863 hasRelatedWork W2030614715 @default.
- W2080180863 hasRelatedWork W2078326109 @default.
- W2080180863 hasRelatedWork W2091984829 @default.
- W2080180863 hasRelatedWork W2124795976 @default.
- W2080180863 hasRelatedWork W2132089800 @default.
- W2080180863 hasRelatedWork W2165429639 @default.
- W2080180863 hasRelatedWork W2332842682 @default.
- W2080180863 hasVolume "244" @default.
- W2080180863 isParatext "false" @default.
- W2080180863 isRetracted "false" @default.
- W2080180863 magId "2080180863" @default.
- W2080180863 workType "article" @default.